Adjuvant Chemotherapy Compared With Observation in Treating Patients With Resected Early Stage Ovarian Epithelial Cancer
Ovarian Cancer
ClinicalTrials.gov recordTREATMENT READING
Source sections for this topic, with the original link and date. Patient and professional reading are labelled separately.
Not medical advice · Not a complete treatment or trial directory
Made by Triangle.
Selected text from the National Cancer Institute, with the original link and date. Made by Triangle. This page is not an NCI PDQ summary. Source topics may be broader than an individual diagnosis.
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
For information about side effects caused by treatment for cancer, visit our Side Effects page.
Sources: side effects · Side Effects
This page is made by Triangle. The reading above is selected source text, not a treatment recommendation, and it is not medical advice.
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
For some people, joining a clinical trial may be an option. There are different types of clinical trials for people with cancer. For example, a treatment trial tests new treatments or new ways of using current treatments. Supportive care and palliative care trials look at ways to improve quality of life, especially for those who have side effects from cancer and its treatment.
You can use the clinical trial search to find NCI-supported cancer clinical trials accepting participants. The search allows you to filter trials based on the type of cancer, your age, and where the trials are being done. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website.
Sources: clinical trial search · ClinicalTrials.gov
Learn more about clinical trials, including how to find and join one, at Clinical Trials Information for Patients and Caregivers.
Sources: Clinical Trials Information for Patients and Caregivers
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
As you go through treatment, you will have follow-up tests or check-ups. Some tests that were done to diagnose or stage the cancer may be repeated to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.
Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the cancer has recurred (come back).
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
For information about the treatments listed below, see the Treatment Option Overview section.
Sources: Treatment Option Overview
Treatment of early ovarian epithelial cancer or fallopian tube cancer may include:
Sources: ovarian epithelial cancer · fallopian tube cancer
Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope for cancer cells. Chemotherapy may be given after surgery.
Sources: Hysterectomy · bilateral salpingo-oophorectomy · omentectomy · Lymph nodes · tissues · pelvis · abdomen · Chemotherapy
Unilateral salpingo-oophorectomy may be done in certain women who wish to have children. Chemotherapy may be given after surgery.
Sources: Unilateral salpingo-oophorectomy
Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.
Sources: clinical trial search · General information
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
For information about the treatments listed below, see the Treatment Option Overview section.
Sources: Treatment Option Overview
Treatment of advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include:
Sources: ovarian epithelial cancer · fallopian tube cancer · primary peritoneal cancer
Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:
Sources: Hysterectomy · bilateral salpingo-oophorectomy · omentectomy · Lymph nodes · tissues · pelvis · abdomen
Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:
Intravenous chemotherapy.
Sources: Intravenous chemotherapy
Intraperitoneal chemotherapy.
Sources: Intraperitoneal chemotherapy
Chemotherapy and targeted therapy (bevacizumab).
Sources: Chemotherapy · targeted therapy · bevacizumab
Chemotherapy and targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor.
Chemotherapy and targeted therapy followed by surgery (possibly followed by intraperitoneal chemotherapy).
Chemotherapy and hyperthermic peritoneal chemotherapy (HIPEC) followed by surgery.
Chemotherapy alone for patients who cannot have surgery.
Targeted therapy with a PARP inhibitor (olaparib, rucaparib, niraparib).
Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.
Sources: clinical trial search · General information
Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 22, 2024. Captured 2026-09-09.
For information about the treatments listed below, see the Treatment Option Overview section.
Sources: Treatment Option Overview
Treatment of recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include:
Sources: recurrent · ovarian epithelial cancer · fallopian tube cancer · primary peritoneal cancer
Chemotherapy using one or more anticancer drugs.
Sources: Chemotherapy
Targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor (olaparib, rucaparib, or niraparib) with or without chemotherapy.
Sources: Targeted therapy · poly (ADP-ribose) polymerase (PARP) inhibitor · olaparib · rucaparib · niraparib
Chemotherapy and/or targeted therapy (bevacizumab).
Sources: bevacizumab
A clinical trial of hyperthermic intraperitoneal chemotherapy (HIPEC) during surgery.
Sources: clinical trial · hyperthermic intraperitoneal chemotherapy
Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.
Sources: clinical trial search · General information
Ovarian Cancer
ClinicalTrials.gov recordOvarian Cancer, Primary Peritoneal Cavity Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
ClinicalTrials.gov recordOvarian Cancer, Primary Peritoneal Cavity Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
ClinicalTrials.gov recordPrimary Peritoneal Carcinoma, Stage III Ovarian Cancer, Stage IV Ovarian Cancer
ClinicalTrials.gov recordPrimary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer, Stage IV Ovarian Epithelial Cancer
ClinicalTrials.gov recordPrimary Peritoneal Carcinoma, Recurrent Ovarian Carcinoma, Stage IV Ovarian Cancer
ClinicalTrials.gov recordEpithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer
ClinicalTrials.gov recordFallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Fallopian...
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
ClinicalTrials.gov recordClear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous...
ClinicalTrials.gov recordOvarian Neoplasms
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
ClinicalTrials.gov recordFallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma, Ovarian Brenner Tumor, Ovarian Clear Cell...
ClinicalTrials.gov recordTumors
ClinicalTrials.gov recordOvarian Epithelial Cancer Recurrent, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordRecurrent Ovarian Cancer
ClinicalTrials.gov recordNewly Diagnosed, Advanced Ovarian Cancer, FIGO Stage III-IV, BRCA Mutation, Complete Response, Partial Response, First Line Platinum Chemotherapy
ClinicalTrials.gov recordOvarian Neoplasms, Platinum Sensitive Ovarian Cancer
ClinicalTrials.gov recordLow-grade Serous Ovarian Cancer, Low-grade Serous Fallopian Tube Cancer, Low-grade Serous Peritoneal Cancer
ClinicalTrials.gov recordPlatinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy
ClinicalTrials.gov recordOvarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
ClinicalTrials.gov recordOvarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
ClinicalTrials.gov recordOvarian Neoplasms, Ovarian Cancer
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordOvarian Cancer, Ovarian Neoplasm
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordEpithelial Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer, Ovarian Cancer
ClinicalTrials.gov recordOvarian Neoplasms
ClinicalTrials.gov recordNeoplasms, Triple Negative Breast Cancer, Ovarian Cancer, Breast Cancer, Metastatic Breast Cancer, Advanced Breast Cancer, Stage IV Breast Cancer, Fallopian Tube Cancer,...
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordOvarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
ClinicalTrials.gov recordOvarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms
ClinicalTrials.gov recordOvarian Cancer
ClinicalTrials.gov recordLow Grade Serous Carcinoma
ClinicalTrials.gov recordLow Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma, Stage II Fallopian Tube Cancer AJCC...
ClinicalTrials.gov recordEpithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
ClinicalTrials.gov recordEpithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
ClinicalTrials.gov recordLow Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer
ClinicalTrials.gov recordOvarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms
ClinicalTrials.gov recordOvarian Neoplasm, Fallopian Tube Neoplasms, Peritoneal Neoplasms
ClinicalTrials.gov recordAbdominal Neoplasm, Colonic Neoplasm, Mesothelioma, Peritoneal Neoplasm
ClinicalTrials.gov recordFallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor, Recurrent Ovarian Carcinoma, Stage III Borderline Ovarian...
ClinicalTrials.gov recordCervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer, Sarcoma, Thromboembolism, Vaginal Cancer, Vulvar Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Female Reproductive Cancer, Ovarian Carcinosarcoma, Ovarian Sarcoma, Recurrent Ovarian Epithelial Cancer, Recurrent Uterine Sarcoma, Stage III Ovarian...
ClinicalTrials.gov recordOvarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer
ClinicalTrials.gov recordBorderline Ovarian Serous Tumor, Low Grade Ovarian Serous Adenocarcinoma, Micropapillary Serous Carcinoma, Primary Peritoneal Carcinoma, Primary Peritoneal Low Grade Serous...
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer
ClinicalTrials.gov recordMixed Mesodermal (Mullerian) Tumor, Ovarian Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Stage I...
ClinicalTrials.gov recordAdult Hepatocellular Carcinoma, Advanced Adult Hepatocellular Carcinoma, Endometrial Serous Adenocarcinoma, Localized Non-Resectable Adult Liver Carcinoma, Lung Carcinoid...
ClinicalTrials.gov recordFallopian Tube Cancer, Ovarian Sarcoma, Ovarian Stromal Cancer, Recurrent Cervical Cancer, Recurrent Endometrial Carcinoma, Recurrent Ovarian Epithelial Cancer, Recurrent...
ClinicalTrials.gov recordBorderline Ovarian Mucinous Tumor, Ovarian Mucinous Cystadenocarcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Stage IA Fallopian Tube Cancer AJCC v6...
ClinicalTrials.gov recordBorderline Ovarian Serous Tumor, Micropapillary Serous Carcinoma, Ovarian Serous Adenocarcinoma, Primary Peritoneal Serous Adenocarcinoma, Recurrent Ovarian Low Grade Serous...
ClinicalTrials.gov recordBrenner Tumor, Malignant Ascites, Malignant Pleural Effusion, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma,...
ClinicalTrials.gov recordAdult Glioblastoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma,...
ClinicalTrials.gov recordAdvanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Melanoma, Advanced Ovarian Carcinoma, Advanced Primary Peritoneal Carcinoma, Advanced Synovial...
ClinicalTrials.gov recordLung Adenocarcinoma, Ovarian Cancer, Peritoneal Carcinoma, Fallopian Tube Cancer, Mesotheliomas Pleural, Mesothelioma Peritoneum
ClinicalTrials.gov recordEndometrial Cancer, Uterine Cancer, Ovarian Cancer, Carcinosarcoma
ClinicalTrials.gov recordOvarian Neoplasms Malignant (Excl Germ Cell), Peritoneal Carcinoma, Fallopian Tube Cancer
ClinicalTrials.gov record1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Alymsys, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent...
1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Avastin, in combination with carboplatin and paclitaxel, followed by Avastin as a single agent, is indicated for the treatment of patients with stage III or IV...
Avastin, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by Avastin as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...
Adult patients with folate receptor-alpha (FRα) positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens. Select patients for therapy...
Fallopian Tube Neoplasm
1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Jobevne, in combination with carboplatin and paclitaxel, followed by Jobevne as a single agent, is indicated for the treatment of patients with stage III or IV...
Jobevne, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by Jobevne as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...
( 1.18 , 2.1 ) Ovarian Cancer in combination with paclitaxel, with or without bevacizumab, is indicated for the treatment of adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma...
1.21 Ovarian Cancer KEYTRUDA, in combination with paclitaxel, with or without bevacizumab, is indicated for the treatment of adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma...
LIFYORLI is a glucocorticoid receptor antagonist indicated in combination with nab-paclitaxel for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to...
1.2 First-line Maintenance Treatment of HRD-positive Advanced Ovarian Cancer in Combination with Bevacizumab Lynparza is indicated in combination with bevacizumab for the maintenance treatment of adult patients with advanced epithelial...
• for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA -mutated advanced epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial...
1.3 Maintenance Treatment of BRCA-mutated Recurrent Ovarian Cancer Lynparza is indicated for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA-mutated recurrent epithelial...
Malignant Fallopian Tube Neoplasm
1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer MVASI, in combination with carboplatin and paclitaxel, followed by MVASI as a single agent, is indicated for the treatment of patients with stage III or IV epithelial...
MVASI, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by MVASI as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian, fallopian...
Primary Peritoneal Carcinoma
1 INDICATIONS AND USAGE RUBRACA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: Ovarian cancer for the maintenance treatment of adult patients with a deleterious BRCA mutation (germline and/or somatic)-associated recurrent...
1.1 Maintenance Treatment of BRCA -mutated Recurrent Ovarian Cancer RUBRACA is indicated for the maintenance treatment of adult patients with a deleterious BRCA mutation (germline and/or somatic)-associated recurrent epithelial ovarian,...
1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer VEGZELMA, in combination with carboplatin and paclitaxel, followed by VEGZELMA as a single agent, is indicated for the treatment of patients with stage III or IV...
VEGZELMA, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by VEGZELMA as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...
1.1 First-Line Maintenance Treatment of HRD-Positive Advanced Ovarian Cancer ZEJULA is indicated for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a...
• for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy and whose cancer is...
1.2 Maintenance Treatment of Recurrent Germline BRCA -Mutated Ovarian Cancer ZEJULA is indicated for the maintenance treatment of adult patients with deleterious or suspected deleterious germline BRCA -mutated (g BRCA mut) recurrent...
1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer ZIRABEV, in combination with carboplatin and paclitaxel, followed by ZIRABEV as a single agent, is indicated for the treatment of patients with stage III or IV...
ZIRABEV, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who...
AVMAPKI FAKZYNJA CO-PACK is indicated for the treatment of adult patients with KRAS -mutated recurrent low-grade serous ovarian cancer (LGSOC) who have received prior systemic therapy. This indication is approved under accelerated...
DailyMed label1. INDICATIONS AND USAGE CYTALUX is indicated as an adjunct for intraoperative identification of: Malignant lesions in adult patients with ovarian cancer. Malignant and non-malignant pulmonary lesions in adult patients with known or...
DailyMed labelELAHERE ® is indicated for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic...
DailyMed labelETHYOL is a cytoprotective agent indicated for: – reduction of cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. ( 1.1 ) – reduction of the incidence of moderate to...
DailyMed labelKYXATA is a platinum-based drug indicated in adults: As part of a combination regimen, for the initial treatment of advanced ovarian carcinoma. ( 1.1 ) As a single-agent for the treatment of ovarian carcinoma recurrent after prior...
DailyMed labelLIFYORLI is indicated in combination with nab-paclitaxel for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment...
DailyMed labelLynparza is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: Ovarian cancer • for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA -mutated advanced epithelial...
DailyMed labelZEJULA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: • for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial...
DailyMed label