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← Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer

TREATMENT READING

Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer, part 2

Source sections for this topic, with the original link and date. Patient and professional reading are labelled separately.

Not medical advice · Not a complete treatment or trial directory

Made by Triangle.

Selected text from the National Cancer Institute, with the original link and date. Made by Triangle. This page is not an NCI PDQ summary. Source topics may be broader than an individual diagnosis.

50 sections
  1. Follow-Up After Treatment
  2. Treatment Option Overview for Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
  3. Capecitabine and Fluorouracil Dosing
  4. Treatment of Low-Grade Serous Carcinoma
  5. Treatment Options for Low-Grade Serous Carcinoma
  6. Surgery with or without chemotherapy
  7. Secondary cytoreductive surgery
  8. Targeted therapies
  9. Treatment of Early-Stage Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
  10. Treatment Options for Early-Stage Ovarian Epithelial Cancer, FTC, and PPC
  11. Surgery with or without chemotherapy
  12. Treatment of Advanced-Stage Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
  13. Treatment Options for Advanced-Stage Ovarian Epithelial Cancer, FTC, and PPC
  14. Surgery followed by platinum-based chemotherapy
  15. Surgery before or after platinum-based chemotherapy and/or additional consolidation therapy
  16. Surgery before or after platinum-based chemotherapy and the addition of bevacizumab to induction and/or consolidation therapy
  17. Surgery after platinum-based chemotherapy and the addition of HIPEC
  18. Surgery before or after platinum-based chemotherapy and the addition of poly (ADP-ribose) polymerase (PARP) inhibitors to induction and/or consolidation therapy
  19. Other consolidation and/or maintenance therapy trials
  20. Treatment options under clinical evaluation
  21. Treatment of Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancer
  22. Treatment Options for Patients with Recurrent or Persistent Ovarian Epithelial Cancer, FTC, and PPC
  23. Platinum-sensitive recurrence
  24. Platinum-containing chemotherapy regimens
  25. Bevacizumab, other targeted drugs, and poly (ADP-ribose) polymerase (PARP) inhibitors with or without chemotherapy
  26. Platinum-refractory or platinum-resistant recurrence
  27. Chemotherapy
  28. Chemotherapy and/or bevacizumab
  29. Immune checkpoint inhibitors
  30. Antibody-drug conjugates
  31. Ovarian epithelial cancer, fallopian tube cancer, and primary peritoneal cancer form in the same type of tissue and are treated the same way.
  32. Certain factors affect treatment options and prognosis (chance of recovery).
  33. Ovarian epithelial, fallopian tube, and primary peritoneal cancers are grouped for treatment as early or advanced cancer.
  34. Ovarian epithelial, fallopian tube, and primary peritoneal cancers can recur (come back) after treatment.
  35. Treatment Option Overview
  36. Key Points
  37. There are different types of treatment for patients with ovarian epithelial cancer.
  38. The following types of treatment are used:
  39. Surgery
  40. Chemotherapy
  41. Targeted therapy
  42. New types of treatment are being tested in clinical trials.
  43. Radiation therapy
  44. Immunotherapy
  45. Treatment for ovarian epithelial, fallopian tube, and primary peritoneal cancers may cause side effects.
  46. Patients may want to think about taking part in a clinical trial.
  47. Follow-up care may be needed.
  48. Treatment of Early Ovarian Epithelial and Fallopian Tube Cancers
  49. Treatment of Advanced Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers
  50. Treatment of Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers

For patients · Treatment Option Overview

Treatment for ovarian epithelial, fallopian tube, and primary peritoneal cancers may cause side effects.

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

For information about side effects caused by treatment for cancer, visit our Side Effects page.

Sources: side effects · Side Effects

This page is made by Triangle. The reading above is selected source text, not a treatment recommendation, and it is not medical advice.

For patients · Treatment Option Overview

Patients may want to think about taking part in a clinical trial.

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

For some people, joining a clinical trial may be an option. There are different types of clinical trials for people with cancer. For example, a treatment trial tests new treatments or new ways of using current treatments. Supportive care and palliative care trials look at ways to improve quality of life, especially for those who have side effects from cancer and its treatment.

You can use the clinical trial search to find NCI-supported cancer clinical trials accepting participants. The search allows you to filter trials based on the type of cancer, your age, and where the trials are being done. Clinical trials supported by other organizations can be found on the ClinicalTrials.gov website.

Sources: clinical trial search · ClinicalTrials.gov

Learn more about clinical trials, including how to find and join one, at Clinical Trials Information for Patients and Caregivers.

Sources: Clinical Trials Information for Patients and Caregivers

For patients · Treatment Option Overview

Follow-up care may be needed.

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

As you go through treatment, you will have follow-up tests or check-ups. Some tests that were done to diagnose or stage the cancer may be repeated to see how well the treatment is working. Decisions about whether to continue, change, or stop treatment may be based on the results of these tests.

Sources: diagnose · stage

Some of the tests will continue to be done from time to time after treatment has ended. The results of these tests can show if your condition has changed or if the cancer has recurred (come back).

For patients

Treatment of Early Ovarian Epithelial and Fallopian Tube Cancers

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

For information about the treatments listed below, see the Treatment Option Overview section.

Sources: Treatment Option Overview

Treatment of early ovarian epithelial cancer or fallopian tube cancer may include:

Sources: ovarian epithelial cancer · fallopian tube cancer

Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope for cancer cells. Chemotherapy may be given after surgery.

Sources: Hysterectomy · bilateral salpingo-oophorectomy · omentectomy · Lymph nodes · tissues · pelvis · abdomen · Chemotherapy

Unilateral salpingo-oophorectomy may be done in certain women who wish to have children. Chemotherapy may be given after surgery.

Sources: Unilateral salpingo-oophorectomy

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Sources: clinical trial search · General information

For patients

Treatment of Advanced Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

For information about the treatments listed below, see the Treatment Option Overview section.

Sources: Treatment Option Overview

Treatment of advanced ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include:

Sources: ovarian epithelial cancer · fallopian tube cancer · primary peritoneal cancer

Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:

Sources: Hysterectomy · bilateral salpingo-oophorectomy · omentectomy · Lymph nodes · tissues · pelvis · abdomen

Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Lymph nodes and other tissues in the pelvis and abdomen are removed and checked under a microscope to look for cancer cells. Surgery is followed by one of the following:

Intravenous chemotherapy.

Sources: Intravenous chemotherapy

Intraperitoneal chemotherapy.

Sources: Intraperitoneal chemotherapy

Chemotherapy and targeted therapy (bevacizumab).

Sources: Chemotherapy · targeted therapy · bevacizumab

Chemotherapy and targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor.

Sources: poly (ADP-ribose) polymerase (PARP) inhibitor

Chemotherapy and targeted therapy followed by surgery (possibly followed by intraperitoneal chemotherapy).

Chemotherapy and hyperthermic peritoneal chemotherapy (HIPEC) followed by surgery.

Chemotherapy alone for patients who cannot have surgery.

Targeted therapy with a PARP inhibitor (olaparib, rucaparib, niraparib).

Sources: olaparib · rucaparib · niraparib

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Sources: clinical trial search · General information

For patients

Treatment of Recurrent or Persistent Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers

Source: Ovarian Epithelial, Fallopian Tube, and Primary Peritoneal Cancers Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: November 22, 2024. Captured 2026-09-09.

For information about the treatments listed below, see the Treatment Option Overview section.

Sources: Treatment Option Overview

Treatment of recurrent ovarian epithelial cancer, fallopian tube cancer, or primary peritoneal cancer may include:

Sources: recurrent · ovarian epithelial cancer · fallopian tube cancer · primary peritoneal cancer

Chemotherapy using one or more anticancer drugs.

Sources: Chemotherapy

Targeted therapy with a poly (ADP-ribose) polymerase (PARP) inhibitor (olaparib, rucaparib, or niraparib) with or without chemotherapy.

Sources: Targeted therapy · poly (ADP-ribose) polymerase (PARP) inhibitor · olaparib · rucaparib · niraparib

Chemotherapy and/or targeted therapy (bevacizumab).

Sources: bevacizumab

A clinical trial of hyperthermic intraperitoneal chemotherapy (HIPEC) during surgery.

Sources: clinical trial · hyperthermic intraperitoneal chemotherapy

Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

Sources: clinical trial search · General information

Studies

Adjuvant Chemotherapy Compared With Observation in Treating Patients With Resected Early Stage Ovarian Epithelial Cancer

NCT00002477 · UNKNOWN · phase3

Ovarian Cancer

ClinicalTrials.gov record

Platinum-based Chemotherapy With or Without Paclitaxel in Treating Patients With Relapsed Ovarian Cancer

NCT00002894 · COMPLETED · phase3

Ovarian Cancer, Primary Peritoneal Cavity Cancer

ClinicalTrials.gov record

Early Chemotherapy Based on CA 125 Level Alone Compared With Delayed Chemotherapy in Treating Patients With Recurrent Ovarian Epithelial , Fallopian Tube, or Primary Peritoneal Cancer

NCT00002895 · COMPLETED · phase3

Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

ClinicalTrials.gov record

Combination Chemotherapy in Treating Patients With Primary Peritoneal or Stage III Epithelial Ovarian Cancer

NCT00003322 · COMPLETED · phase3

Ovarian Cancer, Primary Peritoneal Cavity Cancer

ClinicalTrials.gov record

Chemotherapy Plus Surgery in Treating Patients With Stage III or Stage IV Ovarian, Peritoneal, or Fallopian Tube Cancer

NCT00003636 · COMPLETED · phase3

Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

ClinicalTrials.gov record

Combination Chemotherapy in Treating Patients With Stage III or Stage IV Ovarian Epithelial Cancer or Primary Peritoneal Cancer

NCT00011986 · COMPLETED · phase3

Primary Peritoneal Carcinoma, Stage III Ovarian Cancer, Stage IV Ovarian Cancer

ClinicalTrials.gov record

Bevacizumab in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer or Primary Peritoneal Cancer

NCT00022659 · COMPLETED · phase2

Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer, Stage IV Ovarian Epithelial Cancer

ClinicalTrials.gov record

Bevacizumab and Low-Dose Cyclophosphamide in Treating Patients With Recurrent Ovarian Epithelial or Primary Peritoneal Cancer

NCT00072566 · COMPLETED · phase2

Primary Peritoneal Carcinoma, Recurrent Ovarian Carcinoma, Stage IV Ovarian Cancer

ClinicalTrials.gov record

Trial of Tri-weekly TJ Versus Weekly TJ for Stage II-IV Mullerian Carcinoma

NCT00226915 · COMPLETED · phase3

Epithelial Ovarian Cancer, Primary Peritoneal Cancer, Fallopian Tube Cancer

ClinicalTrials.gov record

Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer

NCT00262847 · COMPLETED · phase3

Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Fallopian...

ClinicalTrials.gov record

Secondary Debulking Surgery +/- Hyperthermic Intraperitoneal Chemotherapy in Stage III Ovarian Cancer

NCT00426257 · COMPLETED · phase3

Ovarian Cancer

ClinicalTrials.gov record

A Study of Carboplatin and Gemcitabine Plus Bevacizumab in Patients With Ovary, Peritoneal, or Fallopian Tube Carcinoma

NCT00434642 · COMPLETED · phase3

Ovarian Cancer

ClinicalTrials.gov record

Carboplatin and Paclitaxel With or Without Bevacizumab in Treating Patients With Newly Diagnosed Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer

NCT00483782 · COMPLETED · phase3

Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer

ClinicalTrials.gov record

Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer

NCT00565851 · ACTIVE NOT RECRUITING · phase3

Clear Cell Adenocarcinoma, Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous...

ClinicalTrials.gov record

Dose-finding Study Comparing Efficacy and Safety of a PARP Inhibitor Against Doxil in BRCA+ve Advanced Ovarian Cancer

NCT00628251 · COMPLETED · phase2

Ovarian Neoplasms

ClinicalTrials.gov record

Study Comparing Weekly Versus Every 3 Week Chemotherapy in Patients With Ovarian Cancer

NCT00660842 · UNKNOWN · phase3

Ovarian Cancer

ClinicalTrials.gov record

AURELIA: A Study of Avastin (Bevacizumab) Added to Chemotherapy in Patients With Platinum-resistant Ovarian Cancer

NCT00976911 · COMPLETED · phase3

Ovarian Cancer

ClinicalTrials.gov record

Study Comparing Tumor Debulking Surgery Versus Chemotherapy Alone in Recurrent Platinum-Sensitive Ovarian Cancer

NCT01166737 · COMPLETED · na

Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer

ClinicalTrials.gov record

Paclitaxel and Carboplatin With or Without Bevacizumab in Treating Patients With Stage II, Stage III, or Stage IV Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer

NCT01167712 · ACTIVE NOT RECRUITING · phase3

Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Transitional Cell Carcinoma, Ovarian Brenner Tumor, Ovarian Clear Cell...

ClinicalTrials.gov record

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Mirvetuximab Soravtansine in Adults With Ovarian Cancer and Other Folate Receptor 1 (FOLR1)-Positive Solid Tumors

NCT01609556 · COMPLETED · phase1

Tumors

ClinicalTrials.gov record

Surgery or Chemotherapy in Recurrent Ovarian Cancer (SOC 1 Trial)?

NCT01611766 · UNKNOWN · phase3

Ovarian Epithelial Cancer Recurrent, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma

ClinicalTrials.gov record

Bevacizumab Beyond Progression in Platinum Sensitive Ovarian Cancer

NCT01802749 · UNKNOWN · phase3

Recurrent Ovarian Cancer

ClinicalTrials.gov record

Olaparib Maintenance Monotherapy in Patients With BRCA Mutated Ovarian Cancer Following First Line Platinum Based Chemotherapy.

NCT01844986 · ACTIVE NOT RECRUITING · phase3

Newly Diagnosed, Advanced Ovarian Cancer, FIGO Stage III-IV, BRCA Mutation, Complete Response, Partial Response, First Line Platinum Chemotherapy

ClinicalTrials.gov record

A Maintenance Study With Niraparib Versus Placebo in Patients With Platinum Sensitive Ovarian Cancer

NCT01847274 · COMPLETED · phase3

Ovarian Neoplasms, Platinum Sensitive Ovarian Cancer

ClinicalTrials.gov record

A Study of MEK162 vs. Physician's Choice Chemotherapy in Patients With Low-grade Serous Ovarian, Fallopian Tube or Peritoneal Cancer

NCT01849874 · TERMINATED · phase3

Low-grade Serous Ovarian Cancer, Low-grade Serous Fallopian Tube Cancer, Low-grade Serous Peritoneal Cancer

ClinicalTrials.gov record

Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

NCT01874353 · ACTIVE NOT RECRUITING · phase3

Platinum Sensitive, BRCA Mutated, Relapsed Ovarian Cancer, Following Complete or Partial Response to Platinum Based Chemotherapy

ClinicalTrials.gov record

A Study of Rucaparib in Patients With Platinum-Sensitive, Relapsed, High-Grade Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer (ARIEL2)

NCT01891344 · COMPLETED · phase2

Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

ClinicalTrials.gov record

Phase 3 Study of Rucaparib as Switch Maintenance After Platinum in Relapsed High Grade Serous or Endometrioid Ovarian Cancer (ARIEL3)

NCT01968213 · COMPLETED · phase3

Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

ClinicalTrials.gov record

A Study of Niraparib in Patients With Ovarian Cancer Who Have Received Three or Four Previous Chemotherapy Regimens

NCT02354586 · COMPLETED · phase2

Ovarian Neoplasms, Ovarian Cancer

ClinicalTrials.gov record

Phase 1/2 Study of Motolimod, Doxorubicin, and Durvalumab in Recurrent, Platinum-Resistant Ovarian Cancer

NCT02431559 · COMPLETED · phase1, phase2

Ovarian Cancer

ClinicalTrials.gov record

Veliparib With Carboplatin and Paclitaxel and as Continuation Maintenance Therapy in Adults With Newly Diagnosed Stage III or IV, High-grade Serous, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT02470585 · TERMINATED · phase3

Ovarian Cancer, Ovarian Neoplasm

ClinicalTrials.gov record

A Study Of Avelumab Alone Or In Combination With Pegylated Liposomal Doxorubicin Versus Pegylated Liposomal Doxorubicin Alone In Patients With Platinum Resistant/Refractory Ovarian Cancer (JAVELIN Ovarian 200)

NCT02580058 · COMPLETED · phase3

Ovarian Cancer

ClinicalTrials.gov record

A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopian Tube Cancer

NCT02631876 · COMPLETED · phase3

Epithelial Ovarian Cancer, Primary Peritoneal Carcinoma, Fallopian Tube Cancer, Ovarian Cancer

ClinicalTrials.gov record

A Study of Niraparib (GSK3985771) Maintenance Treatment in Participants With Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy

NCT02655016 · ACTIVE NOT RECRUITING · phase3

Ovarian Neoplasms

ClinicalTrials.gov record

Niraparib in Combination With Pembrolizumab in Patients With Triple-negative Breast Cancer or Ovarian Cancer

NCT02657889 · COMPLETED · phase1, phase2

Neoplasms, Triple Negative Breast Cancer, Ovarian Cancer, Breast Cancer, Metastatic Breast Cancer, Advanced Breast Cancer, Stage IV Breast Cancer, Fallopian Tube Cancer,...

ClinicalTrials.gov record

Avelumab in Previously Untreated Patients With Epithelial Ovarian Cancer (JAVELIN OVARIAN 100)

NCT02718417 · TERMINATED · phase3

Ovarian Cancer

ClinicalTrials.gov record

ARIEL4: A Study of Rucaparib Versus Chemotherapy BRCA Mutant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Patients

NCT02855944 · COMPLETED · phase3

Ovarian Cancer, Epithelial Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

ClinicalTrials.gov record

A Study of Atezolizumab Versus Placebo in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Participants With Newly-Diagnosed Stage III or Stage IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT03038100 · COMPLETED · phase3

Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Neoplasms

ClinicalTrials.gov record

OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer

NCT03180307 · COMPLETED · phase3

Ovarian Cancer

ClinicalTrials.gov record

Ribociclib and Letrozole Treatment in Ovarian Cancer

NCT03673124 · ACTIVE NOT RECRUITING · phase2

Low Grade Serous Carcinoma

ClinicalTrials.gov record

Letrozole With or Without Paclitaxel and Carboplatin in Treating Patients With Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT04095364 · ACTIVE NOT RECRUITING · phase3

Low Grade Fallopian Tube Serous Adenocarcinoma, Ovarian Low Grade Serous Adenocarcinoma, Primary Peritoneal Low Grade Serous Adenocarcinoma, Stage II Fallopian Tube Cancer AJCC...

ClinicalTrials.gov record

A Study of Mirvetuximab Soravtansine vs. Investigator's Choice (IC) of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha (FRα) Expression

NCT04209855 · COMPLETED · phase3

Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

ClinicalTrials.gov record

A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression

NCT04296890 · COMPLETED · phase3

Epithelial Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer

ClinicalTrials.gov record

A Study of Avutometinib (VS-6766) v. Avutometinib (VS-6766) + Defactinib in Recurrent Low-Grade Serous Ovarian Cancer With and Without a KRAS Mutation

NCT04625270 · ACTIVE NOT RECRUITING · phase2

Low Grade Ovarian Serous Adenocarcinoma, Ovarian Cancer

ClinicalTrials.gov record

Pembrolizumab/Placebo Plus Paclitaxel With or Without Bevacizumab for Platinum-resistant Recurrent Ovarian Cancer (MK-3475-B96/KEYNOTE-B96/ENGOT-ov65).

NCT05116189 · ACTIVE NOT RECRUITING · phase3

Ovarian Cancer, Carcinoma, Ovarian Epithelial, Fallopian Tube Neoplasms

ClinicalTrials.gov record

Relacorilant in Combination With Nab-Paclitaxel in Advanced, Platinum-Resistant, High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian-Tube Cancer

NCT05257408 · ACTIVE NOT RECRUITING · phase3

Ovarian Neoplasm, Fallopian Tube Neoplasms, Peritoneal Neoplasms

ClinicalTrials.gov record

Treatment of Peritoneal Cancer With Surgery, Perfused Heated Cisplatin and Chemotherapy

NCT00004547 · COMPLETED · phase2

Abdominal Neoplasm, Colonic Neoplasm, Mesothelioma, Peritoneal Neoplasm

ClinicalTrials.gov record

Belinostat in Treating Patients With Advanced Ovarian Epithelial Cancer, Primary Peritoneal Cancer, or Fallopian Tube Cancer or Ovarian Low Malignant Potential Tumors

NCT00301756 · COMPLETED · phase2

Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma, Recurrent Borderline Ovarian Surface Epithelial-Stromal Tumor, Recurrent Ovarian Carcinoma, Stage III Borderline Ovarian...

ClinicalTrials.gov record

Fondaparinux in Preventing Blood Clots in Patients Undergoing Surgery for Gynecologic Cancer

NCT00381888 · COMPLETED · phase2

Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer, Sarcoma, Thromboembolism, Vaginal Cancer, Vulvar Cancer

ClinicalTrials.gov record

Ziv-aflibercept in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gynecologic Soft Tissue Sarcoma

NCT00390234 · COMPLETED · phase2

Fallopian Tube Cancer, Female Reproductive Cancer, Ovarian Carcinosarcoma, Ovarian Sarcoma, Recurrent Ovarian Epithelial Cancer, Recurrent Uterine Sarcoma, Stage III Ovarian...

ClinicalTrials.gov record

Letrozole in Patients With Ovarian Tumors

NCT00505661 · TERMINATED · phase2

Ovarian Cancer, Fallopian Tube Cancer, Peritoneal Cancer

ClinicalTrials.gov record

Selumetinib Sulfate in Treating Woman With Recurrent Low-Grade Ovarian Cancer or Peritoneum Cancer

NCT00551070 · COMPLETED · phase2

Borderline Ovarian Serous Tumor, Low Grade Ovarian Serous Adenocarcinoma, Micropapillary Serous Carcinoma, Primary Peritoneal Carcinoma, Primary Peritoneal Low Grade Serous...

ClinicalTrials.gov record

Allogeneic Natural Killer Cells in Patients With Recurrent Ovarian Cancer, Fallopian Tube, and Primary Peritoneal Cancer

NCT00652899 · TERMINATED · phase2

Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cavity Cancer

ClinicalTrials.gov record

Outcomes From Home in Patients Recovering From Major Gynecologic Cancer Surgery: Measuring Symptoms and Health-related Quality of Life

NCT00870233 · COMPLETED · Phase not reported

Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer, Uterine Cancer, Vaginal Cancer, Vulvar Cancer

ClinicalTrials.gov record

Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer

NCT00954174 · UNKNOWN · phase3

Mixed Mesodermal (Mullerian) Tumor, Ovarian Carcinosarcoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma, Stage I...

ClinicalTrials.gov record

Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell Cancer

NCT01010126 · COMPLETED · phase2

Adult Hepatocellular Carcinoma, Advanced Adult Hepatocellular Carcinoma, Endometrial Serous Adenocarcinoma, Localized Non-Resectable Adult Liver Carcinoma, Lung Carcinoid...

ClinicalTrials.gov record

Stereotactic Radiosurgery Using CyberKnife in Treating Women With Advanced or Recurrent Gynecological Malignancies

NCT01079832 · COMPLETED · phase2

Fallopian Tube Cancer, Ovarian Sarcoma, Ovarian Stromal Cancer, Recurrent Cervical Cancer, Recurrent Endometrial Carcinoma, Recurrent Ovarian Epithelial Cancer, Recurrent...

ClinicalTrials.gov record

Carboplatin and Paclitaxel or Oxaliplatin and Capecitabine With or Without Bevacizumab as First-Line Therapy in Treating Patients With Newly Diagnosed Stage II-IV or Recurrent Stage I Epithelial Ovarian or Fallopian Tube Cancer

NCT01081262 · ACTIVE NOT RECRUITING · phase3

Borderline Ovarian Mucinous Tumor, Ovarian Mucinous Cystadenocarcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Stage IA Fallopian Tube Cancer AJCC v6...

ClinicalTrials.gov record

Trametinib in Treating Patients With Recurrent or Progressive Low-Grade Ovarian Cancer or Peritoneal Cavity Cancer

NCT02101788 · COMPLETED · phase2, phase3

Borderline Ovarian Serous Tumor, Micropapillary Serous Carcinoma, Ovarian Serous Adenocarcinoma, Primary Peritoneal Serous Adenocarcinoma, Recurrent Ovarian Low Grade Serous...

ClinicalTrials.gov record

Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

NCT02122185 · COMPLETED · phase2

Brenner Tumor, Malignant Ascites, Malignant Pleural Effusion, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian Mixed Epithelial Carcinoma,...

ClinicalTrials.gov record

TORC1/2 Inhibitor MLN0128 and Bevacizumab in Treating Patients With Recurrent Glioblastoma or Advanced Solid Tumors

NCT02142803 · ACTIVE NOT RECRUITING · phase1

Adult Glioblastoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Ovarian Clear Cell Cystadenocarcinoma, Ovarian Endometrioid Adenocarcinoma,...

ClinicalTrials.gov record

Gene-Modified T Cells With or Without Decitabine in Treating Patients With Advanced Malignancies Expressing NY-ESO-1

NCT02650986 · ACTIVE NOT RECRUITING · phase1, phase2

Advanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Melanoma, Advanced Ovarian Carcinoma, Advanced Primary Peritoneal Carcinoma, Advanced Synovial...

ClinicalTrials.gov record

CAR T Cells in Mesothelin Expressing Cancers

NCT03054298 · COMPLETED · phase1

Lung Adenocarcinoma, Ovarian Cancer, Peritoneal Carcinoma, Fallopian Tube Cancer, Mesotheliomas Pleural, Mesothelioma Peritoneum

ClinicalTrials.gov record

A Study of DKN-01 as a Monotherapy or in Combination With Paclitaxel in Patients With Recurrent Epithelial Endometrial or Epithelial Ovarian Cancer or Carcinosarcoma

NCT03395080 · COMPLETED · phase2

Endometrial Cancer, Uterine Cancer, Ovarian Cancer, Carcinosarcoma

ClinicalTrials.gov record

Trial of Trientine Plus Pegylated Liposomal Doxorubicin and Carboplatin in Epithelial Ovarian Cancer

NCT03480750 · COMPLETED · phase1, phase2

Ovarian Neoplasms Malignant (Excl Germ Cell), Peritoneal Carcinoma, Fallopian Tube Cancer

ClinicalTrials.gov record

Disease and treatment settings

ALYMSYS: recurrent peritoneal cancer

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Alymsys, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent...

Avastin: peritoneal cancer after prior therapy

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Avastin, in combination with carboplatin and paclitaxel, followed by Avastin as a single agent, is indicated for the treatment of patients with stage III or IV...

Avastin: recurrent peritoneal cancer

Disease and treatment setting

Avastin, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by Avastin as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...

Elahere: peritoneal cancer after prior therapy

Disease and treatment setting

Adult patients with folate receptor-alpha (FRα) positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic treatment regimens. Select patients for therapy...

Fallopian Tube Neoplasm

Disease and treatment setting

Fallopian Tube Neoplasm

JOBEVNE: peritoneal cancer after prior therapy

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Jobevne, in combination with carboplatin and paclitaxel, followed by Jobevne as a single agent, is indicated for the treatment of patients with stage III or IV...

JOBEVNE: recurrent peritoneal cancer

Disease and treatment setting

Jobevne, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by Jobevne as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...

KEYTRUDA QLEX: Primary Peritoneal Carcinoma with PD-L1 stated without a specific alteration after prior therapy

Disease and treatment setting

( 1.18 , 2.1 ) Ovarian Cancer in combination with paclitaxel, with or without bevacizumab, is indicated for the treatment of adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma...

KEYTRUDA: Primary Peritoneal Carcinoma with PD-L1 stated without a specific alteration after prior therapy

Disease and treatment setting

1.21 Ovarian Cancer KEYTRUDA, in combination with paclitaxel, with or without bevacizumab, is indicated for the treatment of adult patients with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal carcinoma...

Lifyorli: peritoneal cancer after prior therapy

Disease and treatment setting

LIFYORLI is a glucocorticoid receptor antagonist indicated in combination with nab-paclitaxel for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to...

Lynparza: advanced peritoneal cancer (first-line)

Disease and treatment setting

1.2 First-line Maintenance Treatment of HRD-positive Advanced Ovarian Cancer in Combination with Bevacizumab Lynparza is indicated in combination with bevacizumab for the maintenance treatment of adult patients with advanced epithelial...

Lynparza: advanced peritoneal cancer with BRCA stated without a specific alteration (first-line)

Disease and treatment setting

• for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA -mutated advanced epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial...

Lynparza: recurrent peritoneal cancer with BRCA stated without a specific alteration (maintenance)

Disease and treatment setting

1.3 Maintenance Treatment of BRCA-mutated Recurrent Ovarian Cancer Lynparza is indicated for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA-mutated recurrent epithelial...

Malignant Fallopian Tube Neoplasm

Disease and treatment setting

Malignant Fallopian Tube Neoplasm

MVASI: peritoneal cancer after prior therapy

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer MVASI, in combination with carboplatin and paclitaxel, followed by MVASI as a single agent, is indicated for the treatment of patients with stage III or IV epithelial...

MVASI: recurrent peritoneal cancer

Disease and treatment setting

MVASI, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by MVASI as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian, fallopian...

Primary Peritoneal Carcinoma

Disease and treatment setting

Primary Peritoneal Carcinoma

Rubraca: recurrent peritoneal cancer with BRCA mutation (maintenance)

Disease and treatment setting

1 INDICATIONS AND USAGE RUBRACA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: Ovarian cancer for the maintenance treatment of adult patients with a deleterious BRCA mutation (germline and/or somatic)-associated recurrent...

Rubraca: recurrent peritoneal cancer with BRCA stated without a specific alteration, BRCA mutation (maintenance)

Disease and treatment setting

1.1 Maintenance Treatment of BRCA -mutated Recurrent Ovarian Cancer RUBRACA is indicated for the maintenance treatment of adult patients with a deleterious BRCA mutation (germline and/or somatic)-associated recurrent epithelial ovarian,...

Vegzelma: peritoneal cancer after prior therapy

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer VEGZELMA, in combination with carboplatin and paclitaxel, followed by VEGZELMA as a single agent, is indicated for the treatment of patients with stage III or IV...

Vegzelma: recurrent peritoneal cancer

Disease and treatment setting

VEGZELMA, in combination with carboplatin and paclitaxel, or with carboplatin and gemcitabine, followed by VEGZELMA as a single agent, is indicated for the treatment of patients with platinum-sensitive recurrent epithelial ovarian,...

ZEJULA: advanced peritoneal cancer (first-line)

Disease and treatment setting

1.1 First-Line Maintenance Treatment of HRD-Positive Advanced Ovarian Cancer ZEJULA is indicated for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a...

ZEJULA: advanced peritoneal cancer with BRCA mutation (first-line)

Disease and treatment setting

• for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial response to first-line platinum-based chemotherapy and whose cancer is...

ZEJULA: recurrent peritoneal cancer with BRCA stated without a specific alteration (maintenance)

Disease and treatment setting

1.2 Maintenance Treatment of Recurrent Germline BRCA -Mutated Ovarian Cancer ZEJULA is indicated for the maintenance treatment of adult patients with deleterious or suspected deleterious germline BRCA -mutated (g BRCA mut) recurrent...

Zirabev: peritoneal cancer after prior therapy

Disease and treatment setting

1.6 Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer ZIRABEV, in combination with carboplatin and paclitaxel, followed by ZIRABEV as a single agent, is indicated for the treatment of patients with stage III or IV...

Zirabev: recurrent peritoneal cancer

Disease and treatment setting

ZIRABEV, in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan, is indicated for the treatment of patients with platinum-resistant recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer who...

Drug labels

AVMAPKI FAKZYNJA CO-PACK

Label date 2025-05-01

AVMAPKI FAKZYNJA CO-PACK is indicated for the treatment of adult patients with KRAS -mutated recurrent low-grade serous ovarian cancer (LGSOC) who have received prior systemic therapy. This indication is approved under accelerated...

DailyMed label

Cytalux

Label date 2026-04-01

1. INDICATIONS AND USAGE CYTALUX is indicated as an adjunct for intraoperative identification of: Malignant lesions in adult patients with ovarian cancer. Malignant and non-malignant pulmonary lesions in adult patients with known or...

DailyMed label

ELAHERE

Label date 2025-07-14

ELAHERE ® is indicated for the treatment of adult patients with folate receptor-alpha (FRα) positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, who have received one to three prior systemic...

DailyMed label

Ethyol

Label date 2026-03-03

ETHYOL is a cytoprotective agent indicated for: – reduction of cumulative renal toxicity associated with repeated administration of cisplatin in patients with advanced ovarian cancer. ( 1.1 ) – reduction of the incidence of moderate to...

DailyMed label

KYXATA

Label date 2025-09-02

KYXATA is a platinum-based drug indicated in adults: As part of a combination regimen, for the initial treatment of advanced ovarian carcinoma. ( 1.1 ) As a single-agent for the treatment of ovarian carcinoma recurrent after prior...

DailyMed label

Lifyorli

Label date 2026-03-26

LIFYORLI is indicated in combination with nab-paclitaxel for the treatment of adults with platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who have received one to three prior systemic treatment...

DailyMed label

Lynparza

Label date 2025-07-10

Lynparza is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: Ovarian cancer • for the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA -mutated advanced epithelial...

DailyMed label

ZEJULA

Label date 2026-07-28

ZEJULA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated: • for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in a complete or partial...

DailyMed label