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Treatment Options for Recurrence With Bone-Only Metastases
Source: Osteosarcoma and Undifferentiated Pleomorphic Sarcoma of Bone Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: December 2, 2024 · Captured 2026-09-09.
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Context: Treatment of Recurrent Osteosarcoma and UPS of Bone
Treatment options for patients with osteosarcoma or UPS of bone that has recurred in the bone only include the following:
Surgery to remove the tumor.
153Sm-EDTMP with or without stem cell support.
Chemotherapy or targeted therapy. For more information, see the Chemotherapy and targeted therapy section.
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Radiation therapy.
Patients with osteosarcoma who develop bone metastases have a poor prognosis. In one large series, the 5-year EFS rate was 11%.[68] Patients with late solitary bone relapse have a 5-year EFS rate of approximately 30%.[68-71]
For patients with multiple unresectable bone lesions, 153Sm-EDTMP with or without stem cell support may produce stable disease and/or provide pain relief.[47]
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External-beam radiation therapy can provide local control of recurrent unresectable disease, symptomatic, and/or metastatic disease. Radiation therapy techniques allow for the delivery of very conformal high doses, known as SABR or SBRT. SBRT and SABR administer treatment with high conformality and precision over a short period of time, providing good palliation and local control.[67]
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Preserved source evidence · Not medical advice