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← Osteosarcoma and Undifferentiated Pleomorphic Sarcoma of Bone

FOR PATIENTS · SOURCE READING

Treatment of Recurrent Osteosarcoma and Undifferentiated Pleomorphic Sarcoma (UPS) of Bone

Source: Osteosarcoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: February 25, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Treatment depends on where the cancer recurred and whether it has recurred more than once.

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For tumors that have recurred in the same bone where the cancer started, treatment is surgery.

For tumors that have recurred in the lung only, treatment may include:

For tumors that have recurred in the lung only, treatment may include:

surgery to remove the tumor

For tumors that have recurred in the lung only, treatment may include:

chemotherapy

For tumors that have recurred in the lung only, treatment may include:

radiation therapy

For tumors that have recurred in bones other than where the cancer started, treatment may include:

For tumors that have recurred in bones other than where the cancer started, treatment may include:

surgery to remove the tumor

For tumors that have recurred in bones other than where the cancer started, treatment may include:

chemotherapy

For tumors that have recurred in bones other than where the cancer started, treatment may include:

radiation therapy

For tumors that have recurred in bones other than where the cancer started, treatment may include:

samarium with or without stem cells, as palliative treatment to relieve pain and improve quality of life

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For tumors that have recurred twice, treatment may include:

For tumors that have recurred twice, treatment may include:

surgery to remove the cancer and chemotherapy

For tumors that have recurred twice, treatment may include:

chemotherapy alone

Learn more about these treatments in the Treatment Option Overview.

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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

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Preserved source evidence · Independent clinical review pending · Not medical advice