TriangleFOR PATIENTS · SOURCE READING
Treatment of Metastatic Osteosarcoma and Undifferentiated Pleomorphic Sarcoma (UPS) of Bone
Source: Osteosarcoma Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: February 25, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Lung Metastasis
When osteosarcoma or UPS spreads, it usually spreads to the lung. Treatment of newly diagnosed osteosarcoma and UPS that has spread to the lung may include chemotherapy followed by surgery to remove the primary cancer and more chemotherapy. Then, the doctor will remove the cancer in the lung and give additional chemotherapy.
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Bone Metastasis or Bone with Lung Metastasis
Osteosarcoma and UPS may spread to a distant bone or to both the lung and a distant bone. Treatment of newly diagnosed osteosarcoma and UPS that has spread to a distant bone or to both the lung and a distant bone may include:
Chemotherapy followed by surgery to remove the primary cancer. More chemotherapy is given after surgery. This may be followed by surgery to remove cancer that has spread to other areas of the body.
Surgery to remove the primary cancer, followed by chemotherapy. Then the doctor will remove the cancer that has spread to other parts of the body and give combination chemotherapy.
Surgery alone to remove cancer that has spread to a distant bone.
Radiation therapy.
Learn more about these treatments in the Treatment Option Overview.
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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.
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Preserved source evidence · Independent clinical review pending · Not medical advice