Amputation

Source: Osteosarcoma and Undifferentiated Pleomorphic Sarcoma of Bone Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: December 2, 2024 · Captured 2026-09-09.

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Context: Treatment of Localized Osteosarcoma and UPS of Bone / Treatment Options for Localized Osteosarcoma and UPS of Bone / Surgical removal of primary tumor

For some patients, amputation remains the optimal choice for management of the primary tumor. A pathological fracture noted at diagnosis or during preoperative chemotherapy does not preclude limb-salvage surgery if wide surgical margins can be achieved.[13] If the pathological examination of the surgical specimen shows inadequate margins, an immediate amputation should be considered, especially if the histological necrosis after preoperative chemotherapy was poor.[14]

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