TriangleFOR PATIENTS · SOURCE READING
Having past treatment with chemotherapy or radiation can increase the risk of osteosarcoma.
Source: Osteosarcoma Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: February 25, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
A risk factor is anything that increases the chance of getting a disease. Not every child with one or more of these risk factors will develop osteosarcoma. And it will develop in some children who don't have a known risk factor. Risk factors for osteosarcoma include:
past treatment with chemotherapy or radiation therapy
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having a certain change in the RB1 gene
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having certain conditions, such as:
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having certain conditions, such as:
Diamond-Blackfan anemia
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having certain conditions, such as:
Li-Fraumeni syndrome
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having certain conditions, such as:
hereditary retinoblastoma
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having certain conditions, such as:
Rothmund-Thomson syndrome
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Talk with your child's doctor if you think your child may be at risk.
Preserved source evidence · Independent clinical review pending · Not medical advice