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HEALTH PROFESSIONAL · SOURCE READING

Other systemic consolidation therapies

Source: Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 15, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Stages IIIB and IIIC NSCLC / Treatment Options for Stages IIIB and IIIC NSCLC / Sequential or concurrent chemotherapy and radiation therapy / Systemic consolidation therapy before or after concurrent chemoradiation therapy

The addition of induction chemotherapy before concurrent chemotherapy and radiation therapy has not been shown to improve survival.[18][Level of evidence A1]

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Randomized trials of other consolidation systemic therapies, including docetaxel,[19] gefitinib,[20] and tecemotide (MUC1 antigen-specific immunotherapy) [21] have not shown an improvement in OS.[Level of evidence A1]

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The role of consolidation systemic therapy after concurrent chemotherapy and radiation therapy for unresectable NSCLC remains unclear. Phase III trials of consolidation systemic therapy including conventional chemotherapy (docetaxel),[19] tyrosine kinase inhibitors (gefitinib),[20] and immunotherapy (tecemotide: MUC1 antigen-specific immunotherapy) [21] have not shown an improvement in OS.[Level of evidence A1]

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Preserved source evidence · Not medical advice