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Treatment Options for Stages IIA and IIB NSCLC
Source: Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 15, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment of Stages IIA and IIB NSCLC
Treatment options for stages IIA non-small cell lung cancer (NSCLC) and IIB NSCLC include:
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Surgery with or without adjuvant and/or neoadjuvant therapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Surgery alone.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Adjuvant chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Adjuvant targeted therapy (for patients with EGFR variants).
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Adjuvant targeted therapy (for patients with ALK variants).
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Adjuvant immunotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Adjuvant radiation therapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Neoadjuvant chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Neoadjuvant immunotherapy with chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy. › Neoadjuvant immunotherapy with chemotherapy.
Nivolumab plus platinum-based chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy.
Perioperative (neoadjuvant and adjuvant) immunotherapy with neoadjuvant chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy. › Perioperative (neoadjuvant and adjuvant) immunotherapy with neoadjuvant chemotherapy.
Perioperative pembrolizumab plus platinum-based chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy. › Perioperative (neoadjuvant and adjuvant) immunotherapy with neoadjuvant chemotherapy.
Perioperative durvalumab plus platinum-based chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy. › Perioperative (neoadjuvant and adjuvant) immunotherapy with neoadjuvant chemotherapy.
Perioperative nivolumab plus platinum-based chemotherapy.
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Surgery with or without adjuvant and/or neoadjuvant therapy. › Perioperative (neoadjuvant and adjuvant) immunotherapy with neoadjuvant chemotherapy.
Perioperative toripalimab plus platinum-based chemotherapy.
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Radiation therapy (for patients who cannot have surgery).
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Clinical trials of radiation therapy after curative surgery.
Adjuvant radiation therapy has not been shown to improve outcomes in patients with stage II NSCLC.
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Preserved source evidence · Not medical advice