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FOR PATIENTS · SOURCE READING

Targeted therapy

Source: Neuroblastoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: October 23, 2024 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Treatment Option Overview / The following types of treatment may be used:

Targeted therapy uses drugs or other substances to block the action of specific enzymes, proteins, or other molecules involved in the growth and spread of cancer cells.

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Monoclonal antibody therapy: Monoclonal antibodies are immune system proteins made in the laboratory to treat many diseases, including cancer. As a cancer treatment, these antibodies can attach to a specific target on cancer cells or other cells that may help cancer cells grow. The antibodies are able to then kill the cancer cells, block their growth, or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells.

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Monoclonal antibody therapy: Monoclonal antibodies are immune system proteins made in the laboratory to treat many diseases, including cancer. As a cancer treatment, these antibodies can attach to a specific target on cancer cells or other cells that may help cancer cells grow. The antibodies are able to then kill the cancer cells, block their growth, or keep them from spreading. Monoclonal antibodies are given by infusion. They may be used alone or to carry drugs, toxins, or radioactive material directly to cancer cells.

Dinutuximab is used to treat patients with high-risk neuroblastoma and neuroblastoma that has come back after treatment or has not responded to treatment.

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Ornithine decarboxylase inhibitor therapy slows the growth and division of cancer cells.

Ornithine decarboxylase inhibitor therapy slows the growth and division of cancer cells.

Eflornithine may be given for two years after maintenance therapy for high-risk neuroblastoma.

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Learn more about Targeted Therapy to Treat Cancer.

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Preserved source evidence · Independent clinical review pending · Not medical advice