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FOR PATIENTS · SOURCE READING

Treatment of High-Risk Neuroblastoma

Source: Neuroblastoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: October 23, 2024 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

For information about the treatments listed below, see the Treatment Option Overview section.

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Children with newly diagnosed high-risk neuroblastoma usually receive treatment in three phases: induction, consolidation, and maintenance.

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Treatment during induction may include:

combination chemotherapy

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surgery

Treatment during consolidation may include:

two courses of high-dose combination chemotherapy followed by stem cell rescue

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radiation therapy

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Treatment during maintenance may include monoclonal antibody therapy (dinutuximab), granulocyte-macrophage colony-stimulating factor (GM-CSF), and isotretinoin.

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Treatment after maintenance may include eflornithine.

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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.

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Preserved source evidence · Independent clinical review pending · Not medical advice