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← Myeloproliferative Neoplasms

HEALTH PROFESSIONAL · SOURCE READING

Treatment Options for PMF

Source: Myeloproliferative Neoplasms Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: September 27, 2024 · Captured 2026-09-09.

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Context: Treatment of Primary Myelofibrosis

Treatment options for PMF include:

Ruxolitinib.[37-40]

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Clinical trials involving other JAK2 inhibitors.

Hydroxyurea.[6,7]

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Allogeneic peripheral stem cell or bone marrow transplant.[41-45]

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Thalidomide.[27,32,46-49]

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Lenalidomide.[29,33-35,49]

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Pomalidomide.[36]

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Splenectomy.[50,51]

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Splenic radiation therapy or radiation to sites of symptomatic extramedullary hematopoiesis (e.g., large lymph nodes, cord compression).[7]

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Cladribine.[52]

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Interferon alfa.[53,54]

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Preserved source evidence · Not medical advice