Treatment of Relapsed or Refractory Multiple Myeloma

Watchful waiting for patients whose disease is stable.

A different treatment than treatment already given, for patients whose tumor kept growing during treatment. See Multiple Myeloma treatment options.

The same drugs used before the relapse may be used if the relapse occurs one or more years after initial treatment. See Multiple Myeloma treatment options.

Targeted therapy with monoclonal antibodies (daratumumab, elotuzumab, or isatuximab).

Targeted therapy with proteasome inhibitors (bortezomib, carfilzomib, or ixazomib).

Immunotherapy (pomalidomide, lenalidomide, or thalidomide).

Chemotherapy.

Corticosteroid therapy.

A clinical trial of CAR T-cell therapy.

A clinical trial of targeted therapy with a small molecule inhibitor (selinexor) and corticosteroid therapy.

A clinical trial of targeted therapy with a BCL2 inhibitor (venetoclax).