Radiation therapy

Source: Mycosis Fungoides and Other Cutaneous T-Cell Lymphomas Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: February 19, 2025 · Captured 2026-09-09.

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Context: Treatment of Recurrent Mycosis Fungoides and Sézary Syndrome / Treatment Options for Recurrent Mycosis Fungoides and Sézary Syndrome

Additional electron-beam radiation therapy or a repeat of TSEB.

Electron-beam radiation therapy of appropriate energies will penetrate only to the dermis, and thus, the skin alone can be treated without systemic effects. This therapy requires a radiation therapy facility with physics support and considerable technical expertise to deliver precise dosimetry. TSEB can result in short- and long-term cutaneous toxic effects and is not widely available.

Additional electron-beam radiation therapy or a repeat of TSEB.

This therapy can provide excellent palliation, with complete response rates as high as 80%, and may be combined with systemic treatment. Based on the long-term survival of these early-stage patients, electron-beam radiation therapy is sometimes used with curative intent.[4-8] Long-term disease-free survival (DFS) can be achieved in patients with unilesional mycosis fungoides treated with local radiation therapy.[9]

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Photon radiation to bulky skin or nodal masses.[10]

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Preserved source evidence · Not medical advice