Treatment of Stage III and Stage IV Mycosis Fungoides (Including Sézary Syndrome)

Psoralen and ultraviolet A (PUVA) radiation therapy.

Ultraviolet B radiation therapy.

Extracorporeal photopheresis (ECP) given alone or combined with total skin electron beam radiation therapy.

Radiation therapy with total skin electron beam radiation therapy. In some cases, radiation therapy is given to skin lesions, as palliative therapy to reduce tumor size to relieve symptoms and improve quality of life.

Immunotherapy given alone or combined with therapy directed at the skin.

Systemic chemotherapy with one or more drugs, which may be combined with therapy directed at the skin.

Topical chemotherapy.

Other drug therapy (topical corticosteroids, lenalidomide, bexarotene, histone deacetylase inhibitors).

Targeted therapy with brentuximab vedotin.

A clinical trial of immune checkpoint inhibitor therapy with pembrolizumab.