Treatment Options for Stage III and Stage IV Mycosis Fungoides and Sézary Syndrome

Source: Mycosis Fungoides and Other Cutaneous T-Cell Lymphomas Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: February 19, 2025 · Captured 2026-09-09.

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Context: Treatment of Stage III and Stage IV Mycosis Fungoides and Sézary Syndrome

Treatment options for stages III and IV mycosis fungoides and Sézary syndrome include the following (note that in this clinical setting, the skin is easily injured; any of the topical therapies must be administered with extreme caution):[2,5]

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Photodynamic therapy.

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Photodynamic therapy

Radiation therapy.

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Radiation therapy

Biological therapy.

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Biological therapy

Chemotherapy.

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Chemotherapy

Other drug therapy.

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Other drug therapy

Targeted therapy.

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Targeted therapy

Checkpoint inhibitors.

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Checkpoint inhibitors

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Photodynamic therapy →Radiation therapy →Biological therapy →Chemotherapy →Other drug therapy →Targeted therapy →Checkpoint inhibitors →

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Preserved source evidence · Not medical advice