Treatment of Recurrent Mycosis Fungoides and Sézary Syndrome

The treatment of patients with relapsed mycosis fungoides and Sézary syndrome involves the joint decisions of a dermatologist, medical oncologist, and radiation oncologist. It may be possible to re-treat localized areas of relapse in the skin with additional electron-beam radiation therapy or to repeat total-skin electron-beam radiation therapy (TSEB).[1] Photon radiation to bulky skin or nodal masses may prove beneficial. If these options are not possible, then continued topical treatment with other modalities, such as mechlorethamine or psoralen and ultraviolet A radiation (PUVA) may be warranted to relieve cutaneous symptoms.

Patients should consider clinical trials as a therapeutic option.