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Treatment Options for Localized Malignant Mesothelioma (Stage I)
Source: Malignant Mesothelioma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 12, 2025 · Captured 2026-09-09.
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Context: Treatment of Localized Malignant Mesothelioma (Stage I)
Treatment options for localized malignant mesothelioma (stage I) include:[1]
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Surgery. Solitary mesotheliomas are treated with surgical resection en bloc including contiguous structures to ensure wide disease-free margins. Sessile polypoid lesions are treated with surgical resection to ensure maximal potential for cure.[2] Intracavitary mesotheliomas are treated with extrapleural pneumonectomy.
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Palliative surgery. Pleurectomy and decortication with or without postoperative radiation therapy may be used for intracavitary mesothelioma.
Palliative radiation therapy (for intracavitary mesothelioma).
Intracavitary chemotherapy after resection (under clinical evaluation).[3,4]
Clinical trials.
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Preserved source evidence · Not medical advice