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Treatment Options for Resectable Stage III Melanoma
Source: Melanoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 2, 2025 · Captured 2026-09-09.
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Context: Treatment of Resectable Stage III Melanoma
Treatment options for resectable stage III melanoma include the following:
Excision with or without lymph node management.
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Neoadjuvant therapy.
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Neoadjuvant therapy. › Immunotherapy.
Checkpoint inhibitors.
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Neoadjuvant therapy. › Immunotherapy. › Checkpoint inhibitors.
Pembrolizumab.
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Neoadjuvant therapy. › Immunotherapy. › Checkpoint inhibitors.
Ipilimumab and nivolumab.
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Adjuvant therapy.
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Adjuvant therapy. › Immunotherapy.
Checkpoint inhibitors.
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Adjuvant therapy. › Immunotherapy. › Checkpoint inhibitors.
Nivolumab.
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Adjuvant therapy. › Immunotherapy. › Checkpoint inhibitors.
Pembrolizumab.
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Adjuvant therapy. › Immunotherapy. › Checkpoint inhibitors.
Ipilimumab.
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Adjuvant therapy.
Combination signal transduction inhibitors.
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Adjuvant therapy. › Combination signal transduction inhibitors.
Dabrafenib plus trametinib.
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Combination immunotherapies, including vaccines (under clinical evaluation).
Adjuvant therapies that target a known pathogenic variant (e.g., KIT) (under clinical evaluation).
Intralesional therapies (under clinical evaluation).
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Preserved source evidence · Not medical advice