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Treatment of Stage II Melanoma
Source: Melanoma Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: May 16, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Treatment of stage II melanoma may include:
surgery to remove the tumor and some of the normal tissue around it, with lymph node mapping and sentinel lymph node biopsy. If cancer is found in the sentinel lymph node, more lymph nodes may be removed.
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surgery followed by immunotherapy with pembrolizumab if there is a high risk that the cancer will come back
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Learn more about these treatments in the Treatment Option Overview.
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Use our clinical trial search to find NCI-supported cancer clinical trials that are accepting patients. You can search for trials based on the type of cancer, the age of the patient, and where the trials are being done. General information about clinical trials is also available.
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Preserved source evidence · Independent clinical review pending · Not medical advice