Treatment of Stage III Melanoma That Can Be Removed By Surgery

immunotherapy with pembrolizumab before surgery

surgery to remove the tumor and some of the normal tissue around it, with or without skin grafting to cover the wound caused by surgery. Sometimes lymph node mapping and sentinel lymph node biopsy are done to check for cancer in the lymph nodes at the same time as the surgery to remove the tumor. If cancer is found in the sentinel lymph node, more lymph nodes may be removed.

surgery followed by immunotherapy with nivolumab, pembrolizumab, or ipilimumab if there is a high risk that the cancer will come back

surgery followed by targeted therapy with dabrafenib and trametinib if there is a high risk that the cancer will come back