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Treatment Options for Moderately Advanced Lesions of the Floor of the Mouth
Source: Lip and Oral Cavity Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 14, 2025 · Captured 2026-09-09.
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Context: Treatment of Stage III Lip and Oral Cavity Cancer
Treatment options for stage III moderately advanced lesions of the floor of the mouth include:
Surgery using rim resection plus neck dissection or partial mandibulectomy with neck dissection, as appropriate.
Radiation therapy using EBRT alone or EBRT plus an interstitial implant.
Clinical trials for advanced tumors evaluating the use of chemotherapy preoperatively, before radiation therapy, as adjuvant therapy after surgery, or as part of combined modality therapy are appropriate.[3-6,8-10,12]
Clinical trials using novel radiation therapy fractionation schemas.[13]
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Preserved source evidence · Not medical advice