TriangleHEALTH PROFESSIONAL · SOURCE READING
Management of TSH deficiency
Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 14, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Thyroid hormone replacement therapy using levothyroxine represents the mainstay of treatment of TSH deficiency.
The dose of levothyroxine needs to be adjusted solely using plasma free T4 levels. The levels of TSH are expected to remain low during therapy, given the central nature of this deficiency.
Central hypothyroidism should not be treated before assessment of the functioning of other hypothalamic-pituitary deficiencies, because it could precipitate an adrenal crisis in patients with ACTH deficiency.
Preserved source evidence · Not medical advice