Anthracycline dose equivalency

Traditionally, anthracycline dose equivalence has largely been based on acute hematologic toxicity equivalence rather than late cardiac toxicity.

Analyses that pooled data from more than 28,000 long-term childhood cancer survivors monitored through age 40 years (resulting in 399 cardiomyopathy cases) have challenged previous assumptions that consider daunorubicin equivalent or nearly equivalent to doxorubicin.[36,37]

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Analyses that pooled data from more than 28,000 long-term childhood cancer survivors monitored through age 40 years (resulting in 399 cardiomyopathy cases) have challenged previous assumptions that consider daunorubicin equivalent or nearly equivalent to doxorubicin.[36,37]

These investigations found that daunorubicin may be significantly less cardiotoxic than doxorubicin (equivalence ratio, 0.5; 95% CI, 0.4–0.7).[36]

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Analyses that pooled data from more than 28,000 long-term childhood cancer survivors monitored through age 40 years (resulting in 399 cardiomyopathy cases) have challenged previous assumptions that consider daunorubicin equivalent or nearly equivalent to doxorubicin.[36,37]

Compared with doxorubicin, mitoxantrone may be significantly more cardiotoxic than previously thought (equivalence ratio, 10.5; 95% CI, 6.2–19.1), while epirubicin appeared to be doxorubicin isoequivalent (equivalence ratio, 0.8; 95% CI, 0.3–1.4).[37]

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Analyses that pooled data from more than 28,000 long-term childhood cancer survivors monitored through age 40 years (resulting in 399 cardiomyopathy cases) have challenged previous assumptions that consider daunorubicin equivalent or nearly equivalent to doxorubicin.[36,37]

Data were too sparse to compare idarubicin with doxorubicin.

Publication references