Skip to content
← Late Effects of Treatment for Childhood Cancer (PDQ®)

FOR PATIENTS · SOURCE READING

Surgery

Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Patient Version, National Cancer Institute.

Source updated: February 12, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Musculoskeletal System / Radiation therapy, surgery, chemotherapy, and other treatments increase the risk of bone and joint late effects.

Amputation or limb-sparing surgery to remove the cancer and prevent it from coming back may cause late effects depending on where the tumor was, age of the patient, and type of surgery. Health problems after amputation or limb-sparing surgery may include:

Source links and citations

having problems with activities of daily living

Source links and citations

not being able to be as active as normal

chronic pain

Source links and citations

problems with the way prosthetics fit or work

Source links and citations

broken bone

additional surgeries later in life

the bone not healing well after surgery

one arm or leg is shorter than the other

Studies show no difference in quality of life for childhood cancer survivors who had amputation compared to those who had limb-sparing surgery.

Source links and citations

Preserved source evidence · Independent clinical review pending · Not medical advice