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Methotrexate
Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 14, 2025 · Captured 2026-09-09.
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Context: Late Effects of the Urinary System / Therapy-Related Factors Affecting the Kidney / Chemotherapy
High-dose methotrexate (1,000–33,000 mg/m2) has been reported to cause acute renal dysfunction in up to 12.4% of patients. Long-term renal sequelae have not been described.[21]
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