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← Late Effects of Treatment for Childhood Cancer (PDQ®)

HEALTH PROFESSIONAL · SOURCE READING

HSCT

Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 14, 2025 · Captured 2026-09-09.

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Context: Late Effects of the Digestive System / Hepatobiliary / Treatment-related risk factors for hepatobiliary late effects

Chronic liver dysfunction in patients after HSCT is multifactorial in etiology with the most common etiologies including iron overload, chronic GVHD, and viral hepatitis.[72]

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Patients with chronic GVHD of the GI tract who exhibit an elevated bilirubin have a worse prognosis and quality of life.[73]

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While chronic liver dysfunction may be seen in more than one-half of long-term HSCT survivors, and the course of the disease appears to be indolent, continued follow-up is needed to establish its long-term impact on survivor health.[74]

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Preserved source evidence · Not medical advice