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Certain types of chemotherapy increase the risk of kidney late effects.
Source: Late Effects of Treatment for Childhood Cancer (PDQ®)–Patient Version, National Cancer Institute.
Source updated: February 12, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
The risk of health problems that affect the kidney increases after treatment with:
chemotherapy including cisplatin, carboplatin, ifosfamide, and methotrexate
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radiation therapy to the abdomen or middle of the back
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surgery to remove part or all of a kidney
stem cell transplant
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The risk of kidney late effects is greater in childhood cancer survivors who were treated with a combination of surgery, chemotherapy, or radiation therapy.
The following may also increase the risk of kidney late effects:
having cancer in both kidneys
having a genetic syndrome that increases the risk of kidney problems, such as Denys-Drash syndrome or WAGR syndrome
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being treated with more than one type of treatment
Preserved source evidence · Independent clinical review pending · Not medical advice