TriangleHEALTH PROFESSIONAL · SOURCE READING
Glottis
Source: Laryngeal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 14, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment of Stage III Laryngeal Cancer
Treatment options for stage III cancer of the glottis include:
Concurrent chemoradiation therapy can be considered for patients who would require total laryngectomy for control of disease.[1]
Source links and citations
Neoadjuvant chemotherapy followed by concurrent chemoradiation therapy. Laryngectomy is reserved for patients with less than a 50% response to chemotherapy or who have persistent disease after radiation.[1-6]
Source links and citations
Definitive radiation therapy alone with altered fractionation in patients who are not candidates for concurrent chemotherapy and surgery (total laryngectomy) for salvage of radiation failures.[7]
Source links and citations
Surgery with or without PORT.[8]
Source links and citations
Clinical trials exploring novel targeted therapy, immunotherapy, novel chemotherapy, radiosensitizers, or particle-beam radiation therapy.[9]
Source links and citations
Publication references
Read the original reference and check its publication notices.
Preserved source evidence · Not medical advice