TriangleHEALTH PROFESSIONAL · SOURCE READING
Supraglottis
Source: Laryngeal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 14, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment of Stage III Laryngeal Cancer
Treatment options for stage III cancer of the supraglottis include:
Concurrent chemoradiation therapy can be considered for patients who would require total laryngectomy for control of disease.[1]
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Neoadjuvant chemotherapy followed by concurrent chemoradiation therapy. Laryngectomy is reserved for patients with less than a 50% response to chemotherapy or who have persistent disease following radiation.[1-6][Level of evidence A3]
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Definitive radiation therapy alone with altered fractionation in patients who are not candidates for concurrent chemotherapy and surgery (total laryngectomy) for salvage of radiation failures.[7]
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Surgery with or without postoperative radiation therapy (PORT).[8]
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Publication references
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Preserved source evidence · Not medical advice