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Treatment of Extraocular Extension and Metastatic Intraocular Melanoma
Source: Intraocular (Uveal) Melanoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 16, 2025 · Captured 2026-09-09.
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Extrascleral extension is associated with a poor prognosis. For patients with gross tumor involvement of the orbit, treatment requires orbital exenteration. However, there is no evidence that such radical surgery will prolong survival. Most patients with localized or encapsulated extraocular extension are not exenterated. This subject is controversial.[1-5]
No effective method of systemic treatment has been identified for patients with metastatic ocular melanoma. Clinical trials are an option for these patients.
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