MEN2A syndrome

Source: Childhood Multiple Endocrine Neoplasia (MEN) Syndromes Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 3, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Childhood Multiple Endocrine Neoplasia (MEN) Syndromes / MEN Type 2 (MEN2) Syndromes

For children with MEN2A syndrome, thyroidectomy is commonly performed by approximately age 5 years or older if that is when a RET variant is identified.[2-7] The outcomes for patients with MEN2A syndrome are generally good, although medullary thyroid carcinoma and pheochromocytoma can recur.[8-10]

Source links and citations

A retrospective analysis identified 262 patients with MEN2A syndrome.[11] The median age of the cohort was 42 years and ranged from age 6 to 86 years. There was no correlation between the specific RET variant identified and the risk of distant metastasis. Younger age at diagnosis increased the risk of distant metastasis.

Source links and citations

Young children who are relatives of patients with MEN2A syndrome undergo genetic testing before the age of 5 years. Carriers undergo total thyroidectomy as described above, with autotransplant of one parathyroid gland by a certain age.[12-15]

Source links and citations

Publication references

Read the original reference and check its publication notices.

Preserved source evidence · Not medical advice