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Treatment Option Overview for Endometrial Cancer
Source: Endometrial Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: May 14, 2025 · Captured 2026-09-09.
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The degree of tumor differentiation has an important effect on the natural history of this disease and on treatment selection.
Patients with endometrial cancer who have localized disease are usually cured. Best results are obtained with one of two standard treatments:
Hysterectomy with bilateral salpingo-oophorectomy.
Hysterectomy with bilateral salpingo-oophorectomy and adjuvant radiation therapy (when deep invasion of the myometrial muscle [more than 50% of the myometrium] or grade 3 tumor with myometrial invasion is present).
Patients with regional and distant metastases are rarely cured, although they are occasionally responsive to standard hormone therapy.
Progestational agents have been evaluated as adjuvant therapy in several randomized trials. A meta-analysis by the Cochrane group confirms no clinical benefit to adjuvant progestogens in clinical stage I disease.[1][Level of evidence A1]
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The treatment options for each stage of endometrial cancer are presented in Table 11.
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| Stage (FIGO Staging Definitions) | Treatment Options | |
|---|---|---|
| FIGO = Fédération Internationale de Gynécologie et d’Obstétrique. | ||
| Stage I and stage II endometrial cancer | Grades 1 and 2 | Surgery with or without lymph node sampling |
| Postoperative vaginal brachytherapy | ||
| Radiation therapy alone | ||
| Grade 3 (includes serous, clear cell, and carcinosarcoma) | Surgery | |
| Postoperative chemotherapy with or without radiation therapy | ||
| Stage III, stage IV, and recurrent endometrial cancer | Operable disease | Surgery followed by chemotherapy or radiation therapy |
| Inoperable disease | Chemotherapy and radiation therapy | |
| Inoperable disease in which the patient is not a candidate for radiation therapy | Hormone therapy | |
| Biological therapy | ||
| Advanced or recurrent disease | Immunotherapy | |
| Clinical trials | ||
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- Stage (FIGO Staging Definitions)
- Surgery with or without lymph node sampling
- Postoperative vaginal brachytherapy
- Radiation therapy alone
- Surgery
- Postoperative chemotherapy with or without radiation therapy
- Surgery followed by chemotherapy or radiation therapy
- Chemotherapy and radiation therapy
- Hormone therapy
- Biological therapy
- Immunotherapy
- Clinical trials
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Preserved source evidence · Not medical advice