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← Chronic Myeloid Leukemia

HEALTH PROFESSIONAL · SOURCE READING

Bosutinib

Source: Chronic Myeloid Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: March 13, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Accelerated-Phase CML / Treatment Options for Accelerated-Phase CML / Targeted therapy with TKIs

The U.S. Food and Drug Administration approved bosutinib as a first-line treatment for patients with accelerated-phase CML. These patients were included in the initial phase I/II trial that showed improved efficacy versus imatinib, based on response rates and major molecular response at 5 years of follow-up.[1][Level of evidence C3]

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Bosutinib · Chronic Myeloid Leukemia | Triangle