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Venetoclax plus obinutuzumab versus chlorambucil plus obinutuzumab
Source: Chronic Lymphocytic Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 25, 2025 · Captured 2026-09-09.
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Evidence (venetoclax plus obinutuzumab vs. chlorambucil plus obinutuzumab):
The prospective CLL14 trial (NCT02242942) included 432 previously untreated patients with significant medical comorbidities (6 or higher on the Cumulative Illness Rating Scale; median age, 72 years). Patients were randomly assigned to receive either venetoclax (a highly selective inhibitor of BCL2) plus obinutuzumab (the human anti-CD20 monoclonal antibody) or chlorambucil plus obinutuzumab.[18]
The prospective CLL14 trial (NCT02242942) included 432 previously untreated patients with significant medical comorbidities (6 or higher on the Cumulative Illness Rating Scale; median age, 72 years). Patients were randomly assigned to receive either venetoclax (a highly selective inhibitor of BCL2) plus obinutuzumab (the human anti-CD20 monoclonal antibody) or chlorambucil plus obinutuzumab.[18]
With a median follow-up of 76.4 months, the median PFS rate was 76.2 months for venetoclax plus obinutuzumab, compared with 36.4 months for chlorambucil plus obinutuzumab (HR, 0.40; 95% CI, 0.31–0.52; P < .0001).[18][Level of evidence B1]
Source links and citations
The prospective CLL14 trial (NCT02242942) included 432 previously untreated patients with significant medical comorbidities (6 or higher on the Cumulative Illness Rating Scale; median age, 72 years). Patients were randomly assigned to receive either venetoclax (a highly selective inhibitor of BCL2) plus obinutuzumab (the human anti-CD20 monoclonal antibody) or chlorambucil plus obinutuzumab.[18]
The 6-year OS rate was 78.7% for venetoclax plus obinutuzumab and 69.2% for chlorambucil plus obinutuzumab (HR, 0.69; 95% CI, 0.48–1.01; P = .052).
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Preserved source evidence · Not medical advice