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← Chronic Lymphocytic Leukemia

HEALTH PROFESSIONAL · SOURCE READING

FCR

Source: Chronic Lymphocytic Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 25, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.

Context: Treatment of Symptomatic or Progressive Chronic Lymphocytic Leukemia / Treatment Options for Symptomatic or Progressive Chronic Lymphocytic Leukemia (CLL) / Fludarabine, cyclophosphamide, and rituximab (FCR)

FCR is used for patients with an IGH hypermutation.

Evidence (FCR):

Several trials used FCR for appropriate patients with IGH pathogenic variants who required therapy.

Several trials used FCR for appropriate patients with IGH pathogenic variants who required therapy.

The PFS rate exceeded 60% at more than 10 years.[24-26][Level of evidence C2] Nonetheless, late relapses were seen beyond 10 years.

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Preserved source evidence · Not medical advice