TriangleHEALTH PROFESSIONAL · SOURCE READING
Prognostic factors and prognosis
Source: Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 21, 2025 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary.
Context: Treatment of Chondro-osseous Tumors / Extraskeletal Mesenchymal Chondrosarcoma
A retrospective survey of European institutions identified 113 children and adults with mesenchymal chondrosarcoma. Factors associated with better outcomes included the following:[4][Level of evidence C1]
Source links and citations
Lack of metastatic disease at initial presentation.
Clear resection margins.
Administration of postoperative chemotherapy after resection for patients with initially localized disease.
A retrospective analysis of Surveillance, Epidemiology, and End Results (SEER) Program data from 1973 to 2011 identified 205 patients with mesenchymal chondrosarcoma; 82 patients had skeletal primary tumors, and 123 patients had extraskeletal tumors.[5] The outcomes of patients with skeletal and extraskeletal primary tumors were the same. Factors associated with outcomes included the following:
Source links and citations
Primary site: The 5-year overall survival (OS) rate was 50% for patients with appendicular tumors, 37% for patients with axial tumors, and 74% for patients with cranial tumors.
Metastases and tumor size: Presence of metastatic disease and larger tumor size were independently associated with an increased risk of death.
A single-institution retrospective review identified 43 cases of mesenchymal chondrosarcoma from 1979 to 2010.[6] Thirty patients with localized disease were evaluated. The mean age at diagnosis was 33 years (range, 11–65 years).
Source links and citations
The 5-year OS rate was 51%, and the 10-year OS rate was 37%.
Younger age (<30 years) and male sex were associated with poorer OS and disease-free survival (DFS).
Patients who did not receive adjuvant radiation therapy were more likely to have a local recurrence.
Publication references
Read the original reference and check its publication notices.
Preserved source evidence · Not medical advice