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Histopathological classification
Source: Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 21, 2025 · Captured 2026-09-09.
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Context: Treatment of Adipocytic Tumors / Liposarcoma, Well-Differentiated, Not Otherwise Specified (NOS)
The World Health Organization (WHO) classification for liposarcoma is as follows:[11]
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Intermediate (locally aggressive).
Intermediate (locally aggressive).
Atypical lipomatous tumor. These tumors do not metastasize unless they undergo dedifferentiation.
Malignant.
Malignant.
Dedifferentiated liposarcoma.
Malignant.
Myxoid liposarcoma. Pure myxoid liposarcomas are characterized by a t(12;16)(q13;p11) translocation and can metastasize, but patients usually have an excellent outcome when they do not have a round cell component.[12] Myxoid liposarcoma is the most common subtype of liposarcoma in the pediatric population.[8,9]
Malignant.
Pleomorphic liposarcoma. This is an uncommon type of liposarcoma and primarily arises in older adults.
Malignant.
Myxoid pleomorphic liposarcoma. This rare entity occurs primarily in children, adolescents, and young adults. It commonly presents in the mediastinum and is clinically aggressive.
Malignant.
Liposarcoma, well-differentiated, NOS.
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Preserved source evidence · Not medical advice