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Clinical presentation
Source: Childhood Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 21, 2025 · Captured 2026-09-09.
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Context: Treatment of Tumors of Uncertain Differentiation / Clear Cell Sarcoma NOS
The tumor most commonly affects the lower extremity, particularly the foot, heel, and ankle.[85,86] It has a high propensity for nodal dissemination, especially metastases to regional lymph nodes (12%–43%).[86,87]
The tumor typically has an indolent clinical course. Patients who have small, localized tumors with low mitotic rate and intermediate histological grade have the best outcomes.[88]
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