HEALTH PROFESSIONAL · SOURCE READING

Chemotherapy

Source: Childhood Pancreatic Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: August 13, 2024 · Captured 2026-09-09.

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Context: Pancreatoblastoma / Treatment of Pancreatoblastoma

For large, unresectable, or metastatic tumors, preoperative chemotherapy is indicated. Pancreatoblastoma often responds to chemotherapy. A cisplatin-based regimen is usually recommended. The PLADO regimen, which includes cisplatin and doxorubicin, is most commonly used. Treatment is modeled after the management of hepatoblastoma, with two to three cycles of preoperative therapy, followed by resection and adjuvant chemotherapy.[2,4,10,11]

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Patients with relapsed or persistent pancreatoblastoma have responded to treatment with gemcitabine (one case) [12] and vinorelbine and oral cyclophosphamide (two cases).[13]

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Preserved source evidence · Not medical advice