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Chemotherapy
Source: Childhood Ovarian Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: March 3, 2025 · Captured 2026-09-09.
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Patients with Sertoli-Leydig cell tumors with abdominal spillage during surgery, spontaneous tumor rupture, or metastatic disease (FIGO stages IC, II, III, and IV) are treated with cisplatin-based combination chemotherapy, although the impact of chemotherapy has not been studied in clinical trials in children.[2,10]
One study reported on 40 women (average age, 28 years) with FIGO stage I or IC Sertoli-Leydig cell tumors of the ovary.[29][Level of evidence C1]
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Of 34 patients with intermediate or poor differentiation, 23 patients received postoperative chemotherapy (most regimens included cisplatin). None of these patients experienced disease recurrence.
Of the 11 patients who did not receive postoperative chemotherapy, two had disease recurrence. Both of these patients had tumors that were salvaged with chemotherapy.
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