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← Childhood Non-Hodgkin Lymphoma

TREATMENT READING

Childhood Non-Hodgkin Lymphoma, part 2

Source sections for this topic, with the original link and date. Patient and professional reading are labelled separately.

Not medical advice · Not a complete treatment or trial directory

Made by Triangle.

Selected text from the National Cancer Institute, with the original link and date. Made by Triangle. This page is not an NCI PDQ summary. Source topics may be broader than an individual diagnosis.

85 sections
  1. Response to therapy
  2. Treatment Option Overview for Childhood NHL
  3. Medical Emergencies
  4. Mediastinal masses
  5. Tumor lysis syndrome
  6. Tumor Surveillance
  7. Special Considerations for the Treatment of Children With Cancer
  8. Standard treatment options for Burkitt lymphoma
  9. Treatment options for recurrent or refractory Burkitt lymphoma
  10. Treatment options under clinical evaluation for Burkitt lymphoma
  11. Treatment options for diffuse large B-cell lymphoma
  12. Treatment options for recurrent or refractory diffuse large B-cell lymphoma
  13. Treatment options under clinical evaluation for diffuse large B-cell lymphoma
  14. Treatment options for primary mediastinal B-cell lymphoma
  15. Chemotherapy and rituximab
  16. Radiation therapy
  17. Treatment options for recurrent or refractory primary mediastinal B-cell lymphoma
  18. Treatment options under clinical evaluation for primary mediastinal B-cell lymphoma
  19. Standard Treatment Options for Lymphoblastic Lymphoma
  20. Treatment Options for Recurrent or Refractory Lymphoblastic Lymphoma
  21. Treatment Options Under Clinical Evaluation for Lymphoblastic Lymphoma
  22. Standard Treatment Options for Anaplastic Large Cell Lymphoma
  23. Treatment Options for Recurrent or Refractory Anaplastic Large Cell Lymphoma
  24. Treatment Options Under Clinical Evaluation for Anaplastic Large Cell Lymphoma
  25. Treatment options for lymphoproliferative disease associated with primary immunodeficiency
  26. Treatment options for NHL associated with DNA repair defect syndromes
  27. Treatment options for HIV-associated NHL
  28. Treatment options for PTLD
  29. Treatment options under clinical evaluation for PTLD
  30. Immunodeficiency Associated With Acute Lymphoblastic Leukemia (ALL) Therapy
  31. Treatment options for pediatric-type follicular lymphoma
  32. Treatment options for marginal zone lymphoma (including MALT lymphoma)
  33. Treatment options for primary CNS lymphoma
  34. Treatment options for peripheral T-cell lymphoma
  35. Treatment options for cutaneous T-cell lymphoma
  36. Treatment options for mycosis fungoides
  37. Treatment options for lymphomatoid papulosis
  38. Certain factors affect prognosis (chance of recovery) and treatment options.
  39. Sometimes childhood non-Hodgkin lymphoma does not respond to treatment or recurs (comes back) after treatment.
  40. Treatment Option Overview
  41. Key Points
  42. There are different types of treatment for children with non-Hodgkin lymphoma.
  43. Children with non-Hodgkin lymphoma should have their treatment planned by a team of doctors who are experts in treating childhood cancer.
  44. The following types of treatment may be used:
  45. Surgery
  46. Chemotherapy
  47. Radiation therapy
  48. Stem cell transplant
  49. Targeted therapy
  50. Other drug therapy
  51. Phototherapy
  52. Watchful waiting
  53. Immunotherapy
  54. Treatment for childhood non-Hodgkin lymphoma may cause side effects.
  55. Patients may want to think about taking part in a clinical trial.
  56. Follow-up care may be needed.
  57. Treatment Options for Childhood Non-Hodgkin Lymphoma
  58. Burkitt lymphoma
  59. Treatment of Burkitt lymphoma
  60. Treatment of recurrent or refractory Burkitt lymphoma
  61. Diffuse large B-cell lymphoma
  62. Treatment of diffuse large B-cell lymphoma
  63. Treatment of recurrent or refractory diffuse large B-cell lymphoma
  64. Primary Mediastinal B-cell Lymphoma
  65. Treatment of primary mediastinal B-cell lymphoma
  66. Treatment of recurrent or refractory primary mediastinal B-cell lymphoma
  67. Lymphoblastic Lymphoma
  68. Treatment of lymphoblastic lymphoma
  69. Treatment of recurrent or refractory lymphoblastic lymphoma
  70. Anaplastic Large Cell Lymphoma
  71. Treatment of anaplastic large cell lymphoma
  72. Treatment of recurrent or refractory anaplastic large cell lymphoma
  73. Lymphoproliferative Disease Associated With Immunodeficiency in Children
  74. Treatment of lymphoproliferative disease associated with primary immunodeficiency
  75. Treatment of non-Hodgkin lymphoma associated with DNA repair defect syndromes
  76. Treatment of HIV-associated non-Hodgkin lymphoma
  77. Treatment of post-transplant lymphoproliferative disease
  78. Rare NHL Occurring in Children
  79. Treatment of pediatric-type follicular lymphoma
  80. Treatment of marginal zone lymphoma
  81. Treatment of primary CNS lymphoma
  82. Treatment of peripheral T-cell lymphoma
  83. Treatment of cutaneous T-cell lymphoma
  84. Treatment of mycosis fungoides
  85. Treatment of lymphomatoid papulosis

For patients · Treatment Options for Childhood Non-Hodgkin Lymphoma / Rare NHL Occurring in Children

Treatment of cutaneous T-cell lymphoma

Source: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: May 9, 2025. Captured 2026-09-09.

For information about the treatments listed below, see Treatment Option Overview.

Sources: Treatment Option Overview

Treatment of subcutaneous panniculitis-like T-cell lymphoma in children may include:

Sources: subcutaneous · T-cell lymphoma

watchful waiting

immunotherapy using steroids with or without cyclosporine A or ruxolitinib

Sources: immunotherapy · steroids · cyclosporine A · ruxolitinib

targeted therapy (denileukin diftitox)

Sources: denileukin diftitox

combination chemotherapy

retinoid therapy

Sources: retinoid

stem cell transplant

Sources: stem cell transplant

Treatment of cutaneous anaplastic large cell lymphoma may include surgery, radiation therapy, or both.

Sources: cutaneous · anaplastic large cell lymphoma

This page is made by Triangle. The reading above is selected source text, not a treatment recommendation, and it is not medical advice.

For patients · Treatment Options for Childhood Non-Hodgkin Lymphoma / Rare NHL Occurring in Children

Treatment of mycosis fungoides

Source: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: May 9, 2025. Captured 2026-09-09.

For information about the treatments listed below, see Treatment Option Overview.

Sources: Treatment Option Overview

In children, treatment of mycosis fungoides may include:

Sources: mycosis fungoides

steroids applied to the skin

Sources: steroids

retinoid therapy

Sources: retinoid

radiation therapy

phototherapy (light therapy using ultraviolet B radiation)

Sources: phototherapy · ultraviolet B radiation

For patients · Treatment Options for Childhood Non-Hodgkin Lymphoma / Rare NHL Occurring in Children

Treatment of lymphomatoid papulosis

Source: Childhood Non-Hodgkin Lymphoma Treatment (PDQ®)–Patient Version, National Cancer Institute.

Source updated: May 9, 2025. Captured 2026-09-09.

For information about the treatments listed below, see Treatment Option Overview.

Sources: Treatment Option Overview

In children, treatment of lymphomatoid papulosis may include:

watchful waiting

steroids applied to the skin

phototherapy (light therapy using ultraviolet B radiation)

low doses of chemotherapy (methotrexate)

Studies

Combination Chemotherapy in Treating Children With Lymphoma

NCT00002590 · COMPLETED · phase2

Lymphoma

ClinicalTrials.gov record

TITLE:Less Intensive Therapy for Children With Non-Hodgkin's Lymphoma

NCT00002757 · COMPLETED · phase3

Leukemia, Lymphoma

ClinicalTrials.gov record

Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma

NCT00004228 · COMPLETED · phase3

Lymphoma

ClinicalTrials.gov record

Combination Chemotherapy in Treating Children With Anaplastic Large Cell Lymphoma (ALCL 99)

NCT00006455 · COMPLETED · phase3

Lymphoma

ClinicalTrials.gov record

Rituximab, Rasburicase, and Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Advanced B-Cell Leukemia or Lymphoma

NCT00057811 · COMPLETED · phase2

Childhood Burkitt Lymphoma, Childhood Diffuse Large Cell Lymphoma, Childhood Immunoblastic Large Cell Lymphoma, Stage I Childhood Large Cell Lymphoma, Stage I Childhood Small...

ClinicalTrials.gov record

Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma

NCT00059839 · COMPLETED · phase3

Lymphoma

ClinicalTrials.gov record

Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma

NCT00408005 · COMPLETED · phase3

T Acute Lymphoblastic Leukemia, T Lymphoblastic Lymphoma

ClinicalTrials.gov record

Bortezomib and Combination Chemotherapy in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

NCT00873093 · COMPLETED · phase2

B-cell Adult Acute Lymphoblastic Leukemia, B-cell Childhood Acute Lymphoblastic Leukemia, Recurrent Adult Acute Lymphoblastic Leukemia, Recurrent Adult Lymphoblastic Lymphoma,...

ClinicalTrials.gov record

Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

NCT01000753 · COMPLETED · Phase not reported

Adult Immunoblastic Lymphoma, Central Nervous System Non-Hodgkin Lymphoma, Childhood Immunoblastic Lymphoma, Grade 1 Follicular Lymphoma, Grade 2 Follicular Lymphoma, Grade 3...

ClinicalTrials.gov record

Intergroup Trial for Children or Adolescents With Primary Mediastinal Large B-Cell Lymphoma: DA-EPOCH-Rituximab Evaluation

NCT01516567 · COMPLETED · phase2

Primary Mediastinal Large B Cell Lymphoma

ClinicalTrials.gov record

Intergroup Randomized Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Rituximab Evaluation in High Risk Patients

NCT01516580 · COMPLETED · phase3

B-cell Non Hodgkin Lymphoma, Mature B-cell Leukemia Burkitt-type

ClinicalTrials.gov record

Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma

NCT01979536 · COMPLETED · phase2

Anaplastic Large Cell Lymphoma, ALK-Positive, Ann Arbor Stage II Noncutaneous Childhood Anaplastic Large Cell Lymphoma, Ann Arbor Stage III Noncutaneous Childhood Anaplastic...

ClinicalTrials.gov record

Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma

NCT02112916 · ACTIVE NOT RECRUITING · phase3

Adult T Acute Lymphoblastic Leukemia, Ann Arbor Stage II Adult Lymphoblastic Lymphoma, Ann Arbor Stage II Childhood Lymphoblastic Lymphoma, Ann Arbor Stage III Adult...

ClinicalTrials.gov record

A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy

NCT03394365 · RECRUITING · phase3

Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic...

ClinicalTrials.gov record

Nivolumab in Combination With Chemo-Immunotherapy for the Treatment of Newly Diagnosed Primary Mediastinal B-Cell Lymphoma

NCT04759586 · ACTIVE NOT RECRUITING · phase3

Primary Mediastinal Large B-Cell Lymphoma

ClinicalTrials.gov record

Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia

NCT01008462 · COMPLETED · phase2

B-Cell Prolymphocytic Leukemia, Hypodiploidy, Loss of Chromosome 17p, Plasma Cell Leukemia, Progression of Multiple Myeloma or Plasma Cell Leukemia, Recurrent Adult Hodgkin...

ClinicalTrials.gov record

Selumetinib Sulfate in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating MAPK Pathway Mutations (A Pediatric MATCH Treatment Trial)

NCT03213691 · COMPLETED · phase2

Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, Recurrent Childhood Central Nervous...

ClinicalTrials.gov record

Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations (A Pediatric MATCH Treatment Trial)

NCT03220035 · COMPLETED · phase2

Advanced Malignant Solid Neoplasm, Ann Arbor Stage III Childhood Non-Hodgkin Lymphoma, Ann Arbor Stage IV Childhood Non-Hodgkin Lymphoma, Ependymoma, Ewing Sarcoma,...

ClinicalTrials.gov record

Disease and treatment settings

Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma

Disease and treatment setting

Childhood Nodular Lymphocyte Predominant B-Cell Lymphoma

Childhood Non-Hodgkin Lymphoma

Disease and treatment setting

Non-Hodgkin Lymphoma in children and adolescents

recurrent Childhood Non-Hodgkin Lymphoma

Disease and treatment setting

Treatment options for recurrent or refractory Burkitt lymphoma