FOR PATIENTS · SOURCE READING
Targeted therapy
Source: Childhood Melanoma Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: October 18, 2021 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
Context: Treatment Option Overview / Three types of standard treatment are used:
Targeted therapy is a type of treatment that uses drugs or other substances to attack cancer cells. Targeted therapies usually cause less harm to normal cells than chemotherapy or radiation therapy do. The following type of targeted therapy is being used or studied in the treatment of melanoma:
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Signal transduction inhibitor therapy: Signal transduction inhibitors block signals that are passed from one molecule to another inside a cell. Blocking these signals may kill cancer cells. They are used to treat some patients with advanced melanoma or tumors that cannot be removed by surgery. Signal transduction inhibitors include the following:
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Signal transduction inhibitor therapy: Signal transduction inhibitors block signals that are passed from one molecule to another inside a cell. Blocking these signals may kill cancer cells. They are used to treat some patients with advanced melanoma or tumors that cannot be removed by surgery. Signal transduction inhibitors include the following:
BRAF inhibitors (dabrafenib, vemurafenib , or encorafenib) that block the activity of proteins made by mutant BRAF genes.
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Signal transduction inhibitor therapy: Signal transduction inhibitors block signals that are passed from one molecule to another inside a cell. Blocking these signals may kill cancer cells. They are used to treat some patients with advanced melanoma or tumors that cannot be removed by surgery. Signal transduction inhibitors include the following:
MEK inhibitors (trametinib or binimetinib) that block proteins called MEK1 and MEK2 which affect the growth and survival of cancer cells.
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Preserved source evidence · Independent clinical review pending · Not medical advice
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