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← Childhood Hodgkin Lymphoma

HEALTH PROFESSIONAL · SOURCE READING

Mixed-cellularity Hodgkin lymphoma

Source: Childhood Hodgkin Lymphoma Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 16, 2025 · Captured 2026-09-09.

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Context: Treatment of Newly Diagnosed Children and Adolescents With Hodgkin Lymphoma / Contemporary Treatment of Hodgkin Lymphoma / Histology-based therapy

In addition to variable responses by histology for NLPHL, differences by mixed-cellularity histology have also been observed. COG investigators reported a 4-year EFS rate of 95.2% for children with stage I or stage II mixed-cellularity histology treated with minimal AV-PC therapy (and only rarely requiring radiation therapy). This EFS rate was significantly better than the 75.8% EFS rate for patients who had nodular-sclerosing histology (P = .008).[44]

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