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Radiation Therapy and Chemotherapy
Source: Childhood Colorectal Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: August 27, 2024 · Captured 2026-09-09.
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Context: Treatment of Childhood Colorectal Cancer
Current therapy includes the use of radiation for rectal and lower colon tumors, in conjunction with chemotherapy using fluorouracil (5-FU) with leucovorin.[5] Other agents, including irinotecan, may be of value.[1][Level of evidence C1]
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A review of nine clinical trials involving 138 patients younger than 40 years demonstrated that the use of combination chemotherapy improved progression-free survival and overall survival (OS) in these patients. Furthermore, OS and response rates to chemotherapy were similar to those observed in older patients.[6][Level of evidence B4]
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No significant benefit has been determined for interferon-alfa given in conjunction with 5-FU/leucovorin.[7]
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Preserved source evidence · Not medical advice