TriangleFOR PATIENTS · SOURCE READING
Treatment of Childhood CNS Nongerminomas
Source: Childhood Central Nervous System Germ Cell Tumors Treatment (PDQ®)–Patient Version, National Cancer Institute.
Source updated: November 6, 2024 · Captured 2026-09-09.
Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.
For information about the treatments listed below, see the Treatment Option Overview section.
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It is not clear what treatment is best for newly diagnosed central nervous system (CNS) nongerminomas.
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Treatment of choriocarcinoma, embryonal carcinoma, yolk sac tumor, or mixed germ cell tumor may include:
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Chemotherapy followed by radiation therapy.
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Surgery. If a mass remains after chemotherapy that continues to grow and tumor marker levels are normal (called growing teratoma syndrome), surgery may be needed to check if the mass is part teratoma, fibrosis, or a growing tumor.
Surgery. If a mass remains after chemotherapy that continues to grow and tumor marker levels are normal (called growing teratoma syndrome), surgery may be needed to check if the mass is part teratoma, fibrosis, or a growing tumor.
If the mass is a mature teratoma or fibrosis, radiation therapy is given.
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Surgery. If a mass remains after chemotherapy that continues to grow and tumor marker levels are normal (called growing teratoma syndrome), surgery may be needed to check if the mass is part teratoma, fibrosis, or a growing tumor.
If the mass is a growing tumor, other treatments may be given.
A clinical trial of chemotherapy with radiation therapy to treat patients with CNS nongerminomas that have not spread.
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Preserved source evidence · Independent clinical review pending · Not medical advice