Adjuvant chemotherapy

Source: Childhood Medulloblastoma and Other Central Nervous System Embryonal Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 11, 2025 · Captured 2026-09-09.

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Context: Childhood Medulloblastoma / Treatment of Childhood Medulloblastoma / Treatment of younger children with medulloblastoma

Therapies for younger children with medulloblastoma have included the use of multiagent chemotherapeutic approaches, including drugs such as cyclophosphamide, etoposide, cisplatin, and vincristine, with or without concomitant high-dose intravenous and/or intraventricular methotrexate.[68,81,103,105,107,108]; [109,110][Level of evidence B4] The efficacy of chemotherapy has varied, depending on the histology and/or molecular subtype of the tumor.

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Desmoplastic/MBEN medulloblastoma and/or tumors with SHH signaling →Nondesmoplastic, non-MBEN, and non-SHH signaling–driven medulloblastoma →

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Preserved source evidence · Not medical advice