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← Childhood Medulloblastoma and Other Central Nervous System Embryonal Tumors

HEALTH PROFESSIONAL · SOURCE READING

Adjuvant chemotherapy

Source: Childhood Medulloblastoma and Other Central Nervous System Embryonal Tumors Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: April 11, 2025 · Captured 2026-09-09.

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Context: Childhood Pineoblastoma / Treatment of Childhood Pineoblastoma / Treatment of children older than 3 years

Chemotherapy is usually given in the same way as outlined for high-risk medulloblastomas in children with nondisseminated disease at the time of diagnosis.[15] For more information, see the Treatment of children older than 3 years with high-risk medulloblastoma section.

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The 5-year disease-free survival rate exceeds 50% in children with localized disease at diagnosis who undergo aggressive resection.[13,14,24,25][Level of evidence A1] The Children's Oncology Group (COG) COG-ACNS0332 (NCT00392327) study of 36 patients with nonmedulloblastoma embryonal tumors (which included 26 pineoblastomas) reported a 5-year overall survival (OS) rate of 78.5% (95% confidence interval, 62.2%–94.8%).[25][Level of evidence A1]

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For patients with disseminated disease at the time of diagnosis, survival is considerably poorer.[13,14] In the COG-ACNS0332 (NCT00392327) study, there was no significant difference in event-free survival or OS according to metastatic status.

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Preserved source evidence · Not medical advice