Treatment and Outcome of Childhood Cervical and Vaginal Cancer

Treatment options for childhood carcinoma of the cervix and vagina include the following:

The treatment of choice is surgical resection,[1] followed by radiation therapy for residual microscopic disease or lymphatic metastases. The role of chemotherapy in management is unknown. However, drugs commonly given for the treatment of gynecological malignancies, such as carboplatin and paclitaxel, have been used.[2,3]

In a retrospective report, 37 patients with cervical clear cell adenocarcinoma or cervical mesonephric adenocarcinoma were treated with various modalities (surgery, radiation therapy, and/or chemotherapy). The 3-year event-free survival rate was 71% (± 11%) for patients with all stages of tumors, 82% (± 11%) for patients with stage I and stage II tumors, and 57% (± 22%) for patients with stage III and stage IV tumors.[4]