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Hospitalization
Source: Childhood Acute Myeloid Leukemia Treatment (PDQ®)–Health Professional Version, National Cancer Institute.
Source updated: April 15, 2025 · Captured 2026-09-09.
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Context: Treatment of Childhood AML / Induction Therapy / Supportive care
Hospitalization until adequate granulocyte (absolute neutrophil or phagocyte count) recovery has been used to reduce treatment-related mortality.
The COG-2961 (NCT00002798) trial demonstrated the following:[7]
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The COG-2961 (NCT00002798) trial demonstrated the following:[7]
A significant reduction in treatment-related mortality (19% before mandatory hospitalization was instituted in the trial along with other supportive care changes vs. 12% afterward).
The COG-2961 (NCT00002798) trial demonstrated the following:[7]
OS was also improved in this trial (P < .001).
Another analysis of the impact of hospitalization using a survey of institutional routine practice found the following results:[37]
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Another analysis of the impact of hospitalization using a survey of institutional routine practice found the following results:[37]
Those who mandated hospitalization had nonsignificant reduction in patients' treatment-related mortality (adjusted HR, 0.60 [0.26–1.36, P = .22]) compared with institutions who had no set policy.
Another analysis of the impact of hospitalization using a survey of institutional routine practice found the following results:[37]
Although there was no significant benefit seen in this study, the authors noted the limitations, including its methodology (survey), an inability to validate cases, and limited power to detect differences in treatment-related mortality.
To avoid prolonged hospitalizations until count recovery, some institutions have used outpatient IV antibiotic prophylaxis effectively.[36]
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Preserved source evidence · Not medical advice