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← Childhood Acute Lymphoblastic Leukemia

FOR PATIENTS · SOURCE READING

Chemotherapy

Source: Childhood Acute Lymphoblastic Leukemia (PDQ®)–Patient Version, National Cancer Institute.

Source updated: April 15, 2025 · Captured 2026-09-09.

Selected source text with whitespace normalised. This Triangle page is not an NCI PDQ summary. Independent clinical review is pending.

Context: Types of treatment for childhood acute lymphoblastic leukemia

Chemotherapy (also called chemo) uses drugs to stop the growth of cancer cells. Chemotherapy either kills the cells or stops them from dividing. Chemotherapy may be given alone or with other types of treatment.

For ALL, chemotherapy may be given a few ways. Chemotherapy that is taken by mouth or injected into a vein enters the bloodstream and reaches cancer cells throughout the body. Chemotherapy that is placed directly into the cerebrospinal fluid (intrathecal chemotherapy) mainly affects cancer cells in this area.

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The way the chemotherapy is given depends on your child's risk group. Children with high-risk ALL receive more anticancer drugs and higher doses of anticancer drugs than children with standard-risk ALL. Intrathecal chemotherapy is used to treat childhood ALL that has spread, or may spread, to the brain and spinal cord.

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Chemotherapy drugs used alone or in combination to treat ALL in children include:

asparaginase

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cyclophosphamide

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cytarabine

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daunorubicin

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dexamethasone (steroid)

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doxorubicin

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etoposide

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mercaptopurine

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methotrexate

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nelarabine

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prednisone (steroid)

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thioguanine

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vincristine

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Other drugs not listed here may also be used.

Learn more about how chemotherapy works, how it is given, common side effects, and more at Chemotherapy to Treat Cancer.

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Preserved source evidence · Independent clinical review pending · Not medical advice